A Surgeon's Guide to the Various Antibiotic Dips Available During Penile Prosthesis Implantation.

Abstract

PURPOSE OF REVIEW:

Inflatable penile prosthesis (IPP) is a treatment for erectile dysfunction. IPPs have undergone improvements; however, post-surgical infections still occur. Furthermore, the type of pathogens infecting the implants has changed recently from Gram-positive to Gram-negative bacteria and fungi due to advances in antibiotic dips targeting the skin flora. To protect against infection, the AMS 700 is pre-coated with InhibiZone (mixture of Rifampin/Minocycline) and the Coloplast Titan, with several antibiotic dip options of differing efficacies. This review discusses strategies to decrease the infection rates in implant surgery, focusing on antibiotic dips.

RECENT FINDINGS:

Current research endorses the use of rifampin/gentamicin as the most studied combination; however, some studies have utilized different dips for additional coverage including the InhibiZone on the AMS 700. With the increasing prevalence of diabetes and Gram-negative organisms, there is a need to develop strategies for increased coverage against infections. Controlled studies with different antibiotic combinations are needed to identify the ideal cocktail to decrease infection.

• Authors: Soum D Lokeshwar, Joshua Bitran, Vinayak Madhusoodanan, Bruce Kava, Ranjith Ramasamy
• Journal: Current urology reports (Curr Urol Rep) Vol. 20 Issue 2 Pg. 11 (Jan 30 2019) ISSN: 1534-6285 [Electronic] United States
• PMID: 30701340 (Publication Type: Historical Article, Journal Article, Review)

Chemical References

• Anti-Bacterial Agents
• Coated Materials, Biocompatible
• Delayed-Action Preparations

Topics

• Anti-Bacterial Agents (administration & dosage)
• Coated Materials, Biocompatible
• Delayed-Action Preparations
• Erectile Dysfunction (history, surgery)
• History, 20th Century
• Humans
• Male
• Penile Implantation (history, methods)
• Penile Prosthesis (history, microbiology)
• Prosthesis Design
• Prosthesis-Related Infections (etiology, microbiology, prevention & control)