Objective To summarize the distribution and clinical characteristics of Chinese med- icine (CM) syndrome types in 660 patients with diabetic
peripheral neuropathy (
DPN). Methods Totally 660 inpatients at Department of
Traditional Chinese Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences were recruited from Jan 2000 to Dec 2014. Their first diagnoses were DNP. The distributions of their syndrome types were observed. Clinical characteristics in patients with different syndrome types were compared. Meanwhile, Logistic regression analysis was performed in independent variable by taking syndrome types of CM as quartering regression variables. Results The ratio of syndrome types was sequenced from high to low as
yin deficiency blood stasis syndrome [39.24% (259/660)],
yang deficiency blood stasis syndrome [29.39% (194/60)], phlegm stasis in collaterals syndrome [19. 24% (127/660) ] ,
yin deficiency induced wind stirring syndrome [12. 12% (80/ 660) ]. There was no significant difference in the constituent ratio of CM syndrome patterns among groups with different courses of diabetes (P >0. 05). The ratio of
yang deficiency blood stasis syndrome had an increasing trend as the course increased. There was significant difference in HbAlc, fasting C pep- tide (FCP) , systolic blood pressure (SBP) , total
cholesterol (TC) , 24 h total urinary
protein (24 h UCP) , serum
creatinine (SCr), blood
urea nitrogen (BUN) among patient groups with different CM syndrome types (P <0. 05). Compared with
yang deficiency blood stasis syndrome, HbAlc increased, SBP,SCr,BUN and 24 hUCP decreased in
yin deficiency blood stasis syndrome with statistical difference (P = 0. 006, 0. 002,0. 001 ,0. 001, and 0. 007; P <0. 05) ; 24 h UCP also decreased in
yin deficiency induced wind stirring syndrome (P =0. 34, P <0. 05). Multiclassified Logistic regression showed that when taking
yin deficiency blood stasis syndrome as reference, HbAlc was a protective factor of
yang deficiency blood stasis syn- drome, 8 h urinary
albumin excretion (UAE) was a risk factor. Both TC and SCr were risk factors for
yin deficiency induced wind stirring syndrome. SCr was a risk factor for phlegm stasis in collaterals syndrome. Conclusions Poor control of
blood glucose in
DPN patients might be related with
yin deficiency blood sta- sis syndrome. Patients with
yang deficiency blood stasis syndrome might have longer course of disease, and were correlated with poorer control of SBP and renal function.
DPN patients complicated diabetic ne- phropathy were more liable to have
yang deficiency blood stasis syndrome.