STAT3 rs4796793 contributes to lung cancer risk and clinical outcomes of platinum-based chemotherapy.

Abstract

BACKGROUND:

Signal transducer and activator of transcription (STAT) 3 plays a vital role in carcinogenesis and drug response. Platinum-based chemotherapy is the first-line treatment for lung cancer patients, especially those in advanced stages. In the present study, we investigated the association of STAT3 polymorphism rs4796793 with lung cancer susceptibility, platinum-based chemotherapy response, and toxicity.

METHODS:

A total of 498 lung cancer patients and 213 healthy controls were enrolled in the study. 467 of them received at least 2-cycle platinum-based chemotherapy. Unconditional logistical regression analysis was used to assess the associations.

RESULTS:

STAT3 rs4769793 G allele carriers had an increased susceptibility of lung cancer [additive model: adjusted OR (95% CI) 1.376 (1.058-1.789), P = 0.017; recessive model: adjusted OR (95% CI) 1.734 (1.007-2.985), P = 0.047]. Rs4769793 was not significantly associated with platinum-based chemotherapy response in lung cancer patients. STAT3 rs4796793 was associated with an increased risk of severe overall toxicity [additive model: adjusted OR (95% CI) 1.410 (1.076-1.850), P = 0.013; dominant model: adjusted OR (95% CI) 1.638 (1.091-2.459), P = 0.017], especially hematological toxicity [additive model: adjusted OR (95% CI) 1.352 (1.001-1.826), P = 0.049].

CONCLUSIONS:

STAT3 rs4796793 may be considered as a potential candidate biomarker for the prediction of susceptibility and prognosis in Chinese lung cancer patients. However, well-designed studies with larger sample sizes are required to verify the results.

• Authors: Wei-Jing Gong, Li-Yun Ma, Lei Hu, Yong-Ning Lv, Hong Huang, Jia-Qiang Xu, Dan-Dan Huang, Rui-Jie Liu, Yong Han, Yu Zhang, Shao-Jun Shi, San-Lan Wu
• Journal: International journal of clinical oncology (Int J Clin Oncol) Vol. 24 Issue 5 Pg. 476-484 (May 2019) ISSN: 1437-7772 [Electronic] Japan
• PMID: 30689078 (Publication Type: Journal Article, Meta-Analysis)

Chemical References

• STAT3 Transcription Factor
• STAT3 protein, human
• Platinum

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Asian People (genetics)
• Case-Control Studies
• Female
• Genetic Predisposition to Disease (genetics)
• Humans
• Lung Neoplasms (drug therapy, genetics)
• Male
• Middle Aged
• Platinum (pharmacology)
• Polymorphism, Single Nucleotide
• Prognosis
• STAT3 Transcription Factor
• Treatment Outcome