Mouse models of severe asthma for evaluation of therapeutic cytokine targeting.

Abstract

Severe asthma is a heterogeneous inflammatory disease of the airways, which requires treatment with high-dose inhaled corticosteroids or their systemic administration, yet often remains uncontrolled despite this therapy. Over the past decades, research efforts into phenotyping of severe asthma and defining the pathological mechanisms of this disease were successful largely due to the development of appropriate animal models. Recent identification of distinct inflammatory patterns of severe asthma endotypes led to novel treatment approaches, including targeting specific cytokines or their receptors with neutralizing antibodies. Here we discuss how different experimental mouse models contributed to generation of clinically relevant findings concerning pathogenesis of severe asthma and to identification of potential targets for biologic therapy.

• Authors: Ekaterina O Gubernatorova, Olga A Namakanova, Alexei V Tumanov, Marina S Drutskaya, Sergei A Nedospasov
• Journal: Immunology letters (Immunol Lett) Vol. 207 Pg. 73-83 (03 2019) ISSN: 1879-0542 [Electronic] Netherlands
• PMID: 30659868 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2019 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.

Chemical References

• Anti-Asthmatic Agents
• Antibodies, Monoclonal
• Antibodies, Neutralizing
• Cytokines
• Receptors, Cytokine

Topics

• Animals
• Anti-Asthmatic Agents (therapeutic use)
• Antibodies, Monoclonal (therapeutic use)
• Antibodies, Neutralizing
• Asthma (immunology, therapy)
• Cytokines (immunology, metabolism)
• Disease Models, Animal
• Disease Progression
• Humans
• Immunotherapy (methods)
• Mice
• Receptors, Cytokine (immunology, metabolism)