Abstract | OBJECTIVE: SUBJECTS AND METHODS: RESULTS: In HT, mean TSH was 9.4 ± 26.1 UI/L and levothyroxine treatment was 66.2 ± 30.8 µg/day. The switch to GD was observed 38 ± 45 months after HT diagnosis. As expected, we found significant differences on TSH, FT3, FT4 and TBAb levels. Three out of 14 patients had parietal cell autoantibodies. In two of these three cases there was an Helicobacter pylori infection. There were no significant differences between HT and GD groups with respect to thyroid volume. CONCLUSIONS: To our knowledge, large series documenting the conversion of HT to GD are scarce. Although rare, this phenomenon should not be misdiagnosed. Suspicion should be raised whenever thyroxine posology must be tapered down during the follow-up of HT patients. Further immunological and genetic studies are needed to explain this unusual autoimmune change.
|
Authors | Beatriz Gonzalez-Aguilera, Daniela Betea, Laurence Lutteri, Etienne Cavalier, Vincent Geenen, Albert Beckers, Hernan Valdes-Socin |
Journal | Archives of endocrinology and metabolism
(Arch Endocrinol Metab)
Vol. 62
Issue 6
Pg. 609-614
( 2018)
ISSN: 2359-4292 [Electronic] Brazil |
PMID | 30624501
(Publication Type: Journal Article)
|
Chemical References |
- Autoantibodies
- Immunoglobulins, Thyroid-Stimulating
- Receptors, Thyrotropin
- thyrotropin-binding inhibitory immunoglobulin
- Triiodothyronine
- Thyrotropin
- Thyroxine
|
Topics |
- Adult
- Autoantibodies
(immunology)
- Female
- Graves Disease
(blood, immunology)
- Hashimoto Disease
(blood, immunology)
- Humans
- Hypothyroidism
(immunology)
- Immunoglobulins, Thyroid-Stimulating
(blood, immunology)
- Luminescent Measurements
- Male
- Middle Aged
- Receptors, Thyrotropin
(blood, immunology)
- Retrospective Studies
- Statistics, Nonparametric
- Thyroid Function Tests
- Thyrotropin
(blood)
- Thyroxine
(administration & dosage, blood)
- Triiodothyronine
(blood)
- Young Adult
|