Elevated Periostin Concentrations in the Bronchoalveolar Lavage Fluid of Patients with Eosinophilic Pneumonia.

Abstract

BACKGROUND:

Eosinophilic pneumonia (EP) is characterized by massive pulmonary infiltration by eosinophils. Although serum periostin is a novel marker for eosinophil-dominant asthma, the upregulation of periostin in the airway of asthmatics is controversial. In this study, we examined whether periostin concentrations are elevated in the bronchoalveolar lavage fluid (BALF) of patients with EP.

METHODS:

BAL was performed in healthy volunteers and in patients with acute eosinophilic pneumonia (AEP), chronic eosinophilic pneumonia (CEP), and sarcoidosis. The periostin concentrations in the BALF were measured.

RESULTS:

The periostin concentration in the BALF increased significantly with pulmonary eosinophil ia and was higher in AEP and CEP patients than in healthy volunteers and sarcoidosis patients, even after adjusting the albumin concentration. In pulmonary eosinophilia, the periostin concentration correlated with the eosinophil and lymphocyte counts, the concentration of albumin, and the concentration of cytokines such as IL-5, IL-13, and transforming growth factor β1.

CONCLUSIONS:

Although some blood leakage may be involved in the elevation of periostin in the BALF of EP, periostin can be induced locally, at least in part. Therefore, periostin may play a role in the development of EP.

• Authors: Kazuyuki Nakagome, Yutaka Nakamura, Takehito Kobayashi, Shoichiro Ohta, Junya Ono, Kiyoko Kobayashi, Kenji Ikebuchi, Toru Noguchi, Tomoyuki Soma, Kohei Yamauchi, Kenji Izuhara, Makoto Nagata
• Journal: International archives of allergy and immunology (Int Arch Allergy Immunol) 2019 Vol. 178 Issue 3 Pg. 264-271 ISSN: 1423-0097 [Electronic] Switzerland
• PMID: 30612125 (Publication Type: Journal Article)
• Copyright: © 2019 S. Karger AG, Basel.

Chemical References

• Cell Adhesion Molecules
• Cytokines
• POSTN protein, human
• Serum Albumin

Topics

• Adult
• Bronchoalveolar Lavage Fluid (chemistry)
• Cell Adhesion Molecules (analysis, physiology)
• Cytokines (analysis)
• Eosinophils (physiology)
• Female
• Humans
• Lymphocyte Count
• Male
• Middle Aged
• Pulmonary Eosinophilia (etiology, immunology)
• Serum Albumin (analysis)