CSF TACI and BAFF levels in patients with primary CNS lymphoma as novel diagnostic biomarkers.

Abstract

We used an enzyme-linked immunosorbent assay to measure pretreatment B cell-activating factor belonging to the tumour necrosis factor family (BAFF) and transmembrane activator and CAML-interactor (TACI) levels in CSF and serum collected from patients with primary central nervous system lymphoma (PCNSL) and control groups. The decision tree analysis of CSF TACI and BAFF levels for patients with a PCNSL diagnosis showed 100% sensitivity and 100% specificity when we attempted to differentiate PCNSL from glioblastoma and CNS inflammatory diseases. The combination of CSF TACI and BAFF levels may thus be a novel and useful diagnostic biomarker of PCNSL.

• Authors: Hironori Mizutani, Shunya Nakane, Tokunori Ikeda, Hideo Nakamura, Koutaro Takamatsu, Keishi Makino, Nozomu Tawara, Akihiro Mukaino, Mari Watari, Hirotaka Matsui, Akitake Mukasa, Yukio Ando
• Journal: Annals of clinical and translational neurology (Ann Clin Transl Neurol) Vol. 5 Issue 12 Pg. 1611-1616 (Dec 2018) ISSN: 2328-9503 [Print] United States
• PMID: 30564626 (Publication Type: Journal Article)