Serial measurements of KL-6 for monitoring activity and recurrence of interstitial pneumonia with anti-aminoacyl-tRNA synthetase antibody: A retrospective cohort study.

Abstract

The aim of this study was to evaluate whether serial measurements of serum Krebs von den Lungen-6 (KL-6) could be used to monitor disease activity and to detect recurrence in patients with interstitial pneumonia (IP) with anti-aminoacyl-tRNA synthetase antibodies (ARS-IP).This retrospective cohort study included 44 patients with ARS-IP. Thirty-six patients had serial data of blood tests and pulmonary function tests. Baseline and longitudinal analyses were performed to investigate whether lung function parameters were associated with serum biomarkers (KL-6, lactate dehydrogenase [LDH], and C-reactive protein [CRP]) using Pearson correlation coefficient. Additionally, the diagnostic accuracy of changes in these biomarkers for detecting ARS-IP recurrence was analyzed by receiver operating characteristic curve analysis.Baseline levels of serum KL-6 were significantly associated with vital capacity (VC) and diffusion capacity for carbon monoxide (DLco) (r = -0.40, P = .015, and r = -0.44, P = .010, respectively). Longitudinal changes in KL-6 were inversely correlated with changes in VC and DLco (r = -0.57, P <.001 and r = -0.42, P <.001, respectively), whereas those in LDH and CRP were not. Moreover, longitudinal changes in serum KL-6 were significantly associated with recurrence of ARS-IP and could be used to detect ARS-IP recurrence; the area under the curve was 0.79 (P = .002).The present study demonstrated that serial measurement of KL-6 is useful for monitoring disease activity and detecting recurrence of ARS-IP.

• Authors: Kakuhiro Yamaguchi, Hiroshi Iwamoto, Shinjiro Sakamoto, Yasushi Horimasu, Takeshi Masuda, Shintaro Miyamoto, Taku Nakashima, Shinichiro Ohshimo, Kazunori Fujitaka, Hironobu Hamada, Nobuoki Kohno, Noboru Hattori
• Journal: Medicine (Medicine (Baltimore)) Vol. 97 Issue 49 Pg. e13542 (Dec 2018) ISSN: 1536-5964 [Electronic] United States
• PMID: 30544464 (Publication Type: Case Reports, Journal Article)

Chemical References

• Autoantibodies
• Biomarkers
• MUC1 protein, human
• Mucin-1
• Amino Acyl-tRNA Synthetases

Topics

• Adult
• Aged, 80 and over
• Amino Acyl-tRNA Synthetases (immunology)
• Autoantibodies (blood)
• Biomarkers (blood)
• Female
• Humans
• Longitudinal Studies
• Lung Diseases, Interstitial (blood, drug therapy, immunology)
• Male
• Middle Aged
• Mucin-1 (blood)
• Recurrence
• Retrospective Studies