Cerebrospinal fluid interleukin (IL)-10 and IL-10:IL-6 ratio as biomarkers for small B-cell lymphoproliferations with leptomeningeal dissemination.

Abstract

We here report for the first time that low levels of interleukin (IL)-10 do not exclude lymphomatous meningitis (LM) in B-cell lymphoproliferative disorders (CLPD). Unexpectedly, IL-10 levels and IL-10:IL-6 ratio in CLPD differed from the levels observed in diffuse large B-cell lymphoma (DLBCL). We report the usefulness of adding the IL-10:IL-6 ratio in order to potentially reveal more aggressive lymphomas: either a transformation or an association with another "hidden" lymphoma such as primary CNS lymphoma (PCNSL).

• Authors: Myrto Costopoulos, Rathana Kim, Sylvain Choquet, Karim Maloum, Caroline Houillier, Caroline Algrin, Catherine Settegrana, Juliette Villemonteix, Martine Brissard, Claire Quiney, Sophie Bernard, Frederic Davi, Catherine Thieblemont, Khe Hoang-Xuan, Veronique Leblond, Helene Merle-Beral, Magali Le Garff-Tavernier
• Journal: Seminars in hematology (Semin Hematol) Vol. 55 Issue 4 Pg. 179-181 (10 2018) ISSN: 1532-8686 [Electronic] United States
• PMID: 30502843 (Publication Type: Journal Article, Multicenter Study)
• Copyright: Copyright © 2017 Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers
• Interleukin-6
• Interleukin-10

Topics

• Aged
• Aged, 80 and over
• Biomarkers (cerebrospinal fluid)
• Central Nervous System Neoplasms (diagnosis, pathology)
• Female
• Humans
• Interleukin-10 (metabolism)
• Interleukin-6 (metabolism)
• Male
• Middle Aged