Abstract | BACKGROUND: PROCEDURE: This study explores the safety and feasibility of the KD in children with recurrent DIPG and no remaining treatment options. Safety was defined as the number of adverse effects. Feasibility was defined as the number of patients who were able to use the KD for three months. Coping of patients and parents was measured with questionnaires. RESULTS: Three of 14 children referred to our hospital between 2010 and 2015 were included. Two patients completed the study, and one died before the end of the study. Hospitalizations were needed for placing a nasogastric tube (n = 1) and epileptic seizures (n = 1). Adverse effects related to the diet were mild and transient. Parents were highly motivated during the study. CONCLUSION: Use of KD is safe and feasible, but the effect on survival has to be proven in a larger cohort of children who start the KD earlier after diagnosis, preferably as adjuvant therapy to fractionated radiotherapy.
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Authors | Elles J T M van der Louw, Roel E Reddingius, Joanne F Olieman, Rinze F Neuteboom, Coriene E Catsman-Berrevoets |
Journal | Pediatric blood & cancer
(Pediatr Blood Cancer)
Vol. 66
Issue 3
Pg. e27561
(03 2019)
ISSN: 1545-5017 [Electronic] United States |
PMID | 30484948
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2018 The Authors. Pediatric Blood & Cancer Published by Wiley Periodicals, Inc. |
Topics |
- Adolescent
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Brain Stem Neoplasms
(complications, pathology, therapy)
- Chemoradiotherapy
- Chemotherapy, Adjuvant
- Child
- Child, Preschool
- Diet, Ketogenic
(methods)
- Feasibility Studies
- Follow-Up Studies
- Glioma
(complications, pathology, therapy)
- Humans
- Incidence
- Male
- Neoplasm Recurrence, Local
(diagnosis, diet therapy, epidemiology)
- Netherlands
(epidemiology)
- Prognosis
- Prospective Studies
- Radiotherapy
- Safety
- Survival Rate
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