Ketogenic Diet

A course of food intake that is high in FATS and low in CARBOHYDRATES. This diet provides sufficient PROTEINS for growth but insufficient amount of carbohydrates for the energy needs of the body. A ketogenic diet generates 80-90% of caloric requirements from fats and the remainder from proteins.

Also Known As:

Networked: 1014 relevant articles (206 outcomes, 124 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Kossoff, Eric H: 57 articles (01/2016 - 05/2002)
2.	Kim, Heung Dong: 26 articles (02/2015 - 09/2004)
3.	Pyzik, Paula L: 19 articles (08/2011 - 05/2002)
4.	Rho, Jong M: 18 articles (01/2015 - 06/2003)
5.	Hartman, Adam L: 18 articles (02/2014 - 09/2006)
6.	Turner, Zahava: 16 articles (01/2016 - 05/2007)
7.	Cross, J Helen: 16 articles (11/2015 - 06/2008)
8.	Rubenstein, James E: 15 articles (05/2013 - 08/2004)
9.	Freeman, John M: 15 articles (01/2010 - 05/2002)
10.	Vining, Eileen P G: 15 articles (09/2009 - 05/2002)

Related Diseases

1.	Epilepsy (Aura) 08/01/2015 - "A growing body of evidence demonstrates that dietary therapies, mainly the ketogenic diet, may be highly effective in the reduction of epileptic seizures. " 01/01/2012 - "The most notable example of a dietary treatment with proven efficacy against a neurological condition is the high-fat, low-carbohydrate ketogenic diet (KD) used in patients with medically intractable epilepsy. " 05/01/2011 - "The ketogenic diet remains one of the most effective treatments for medically refractory childhood epilepsy. " 11/01/2008 - "The ketogenic diet (KD) has shown remarkable efficacy in the treatment of drug-resistant childhood epilepsy. " 08/01/2007 - "Although highly effective for the treatment of intractable epilepsy, the ketogenic diet is not always included in the treatment option hierarchy presented to families, in part due to perceptions that children will find the high-fat/low-carbohydrate regimen unpalatable. "
2.	Seizures (Seizure) 09/01/2001 - "Most reports of the ketogenic diet have focused on its efficacy for generalized seizures. " 10/01/2001 - "Three to 6 years after initiation, the ketogenic diet had proven to be effective in the control of difficult-to-control seizures in children. " 04/01/2000 - "The results of these studies are consistent in showing that some children benefit from the ketogenic diet, demonstrated by a significant reduction in seizure frequency. " 06/01/2014 - "Fifty-two percent of patients had a significant reduction in seizure frequency on the ketogenic diet, including 45% with ≥50% reduction in seizure frequency. " 11/01/1998 - "The ketogenic diet is effective in substantially decreasing difficult-to-control seizures and can successfully be administered in a wide variety of settings."
3.	Weight Loss (Weight Reduction) 12/01/2014 - "This result suggests that weight loss by 3 weeks of calorie restriction and exercise can cause oxidative stress, and that ketogenic diet can be effective for preventing it. " 06/16/2006 - "Low-carbohydrate, ketogenic diets (LCKD) are effective for weight loss, but concerns remain regarding cardiovascular risk. " 01/01/2009 - "Ketogenic diets have been utilized for weight loss and improvement in metabolic parameters. " 03/01/2008 - "This review includes a brief overview of ketone body metabolism, and summarises the literature regarding the safety and efficacy of ketogenic diets for weight loss.:" 10/01/2013 - "Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials."
4.	Infantile Spasms (West Syndrome) 01/01/2013 - "For infantile spasms (West syndrome) specifically, the ketogenic diet is successful about 50% of the time as a first-line treatment. " 05/01/2002 - "Efficacy of the ketogenic diet for infantile spasms." 09/01/2013 - "The aim of this study was to provide additional evidences on prognostic factors for infantile spasms and the possible role of a ketogenic diet. " 04/01/2011 - "To compare the prognoses between short-term (8 months) and conventional long-term (> 2 years) trials involving patients with refractory infantile spasms who successfully completed the ketogenic diet (KD). " 10/01/2006 - "This study sought to evaluate the efficacy, tolerability, and safety of a ketogenic diet (KD) in the treatment of infantile spasms (IS), incorporating a revised protocol based on our previous experience with KD. "
5.	Ketosis 11/01/1999 - "These results suggest that the efficacy of the ketogenic diet is independent of the level of ketonemia but is markedly influenced by diet and growth." 01/01/2015 - "To evaluate quantitatively the effect of ketogenic diets on subjective appetite ratings, we conducted a systematic literature search and meta-analysis of studies that assessed appetite with visual analogue scales before (in energy balance) and during (while in ketosis) adherence to VLED or KLCD. " 04/01/2011 - "Our Italian collaborative study group was set up in order to formulate a consensus statement regarding the clinical management of the ketogenic diet, patient selection, pre-ketogenic diet, counseling, setting and enforcement of dietary induction of ketosis, follow-up management, and eventual discontinuation of the diet." 01/01/2015 - "Ketogenic diets like low carbohydrate, high fat may induce ketoacidosis. " 01/01/2015 - "Ketosis, ketogenic diet and food intake control: a complex relationship."

Related Drugs and Biologics

1.	Glucose (Dextrose)
2.	Anticonvulsants (Antiepileptic Drugs)
3.	Lactic Acid
4.	Facilitative Glucose Transport Proteins (Glucose Transporter)
5.	Insulin (Novolin)
6.	topiramate (Topamax)
7.	Valproic Acid (Valproate, Semisodium)
8.	Vigabatrin
9.	lamotrigine (Lamictal)
10.	Pyruvic Acid (Pyruvate)

Related Therapies and Procedures

1.	Carbohydrate-Restricted Diet (Low Carbohydrate Diet)
2.	Caloric Restriction
3.	Ketogenic Diet
4.	Gastrostomy
5.	Enteral Nutrition (Feeding, Tube)