Two Cases of 188Re Microspheres for Inoperable Hepatocellular Carcinoma.

Abstract

Hepatocellular carcinoma (HCC) is one of the most lethal malignancies. Often, patients present with inoperable and advanced disease. Selective internal radionuclide therapy offers prolonged survival and improved quality of life by delivering high radiation dose to the tumor with minimal complications. We report 2 inoperable cases of HCC treated with therapeutic dose of indigenously developed Re microspheres delivered to the hepatic lesions by transarterial catheterization. Follow-up CT revealed necrosis within the lesion, suggesting response to selective internal radionuclide therapy. Re microspheres may be a potential treatment option for inoperable HCC with or without portal vein thrombosis.

• Authors: Jaya Shukla, Naveen Kalra, Rajender Kumar, Priya Bhusari, Anupriya Chhabra, Madan Parmar, Rakhee Vatsa, Harmandeep Singh, Ajay Duseja, B R Mittal
• Journal: Clinical nuclear medicine (Clin Nucl Med) Vol. 44 Issue 2 Pg. e93-e95 (Feb 2019) ISSN: 1536-0229 [Electronic] United States
• PMID: 30418210 (Publication Type: Case Reports, Journal Article)

Chemical References

• Radioisotopes
• Rhenium-188
• Rhenium

Topics

• Carcinoma, Hepatocellular (pathology, radiotherapy, surgery)
• Female
• Humans
• Liver Neoplasms (pathology, radiotherapy, surgery)
• Male
• Microspheres
• Middle Aged
• Quality of Life
• Radioisotopes (adverse effects, therapeutic use)
• Rhenium (adverse effects, therapeutic use)
• Treatment Outcome