A Higher Fructose Intake Is Associated with Greater Albuminuria in Subjects with Type 2 Diabetes Mellitus.

Abstract

The aim of this single center cross-sectional study was to investigate the association between fructose intake and albuminuria in subjects with type 2 diabetes mellitus (T2DM). This is a single center cross-sectional study. One hundred and forty-three subjects with T2DM were recruited from the Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran. The median daily fructose intake was estimated with a prospective food registry during 3 days (2 week-days and one weekend day) and they were divided into low fructose intake (<25 g/day) and high fructose intake (≥ 25 g/day). Complete clinical and biochemical evaluations were performed, including anthropometric variables and a 24-hour urine collection for albuminuria determination. One hundred and thirty-six subjects were analyzed in this study. We found a positive significant association between daily fructose intake and albuminuria (ρ= 0.178, p=0.038) in subjects with type 2 diabetes mellitus. Other variables significantly associated with albuminuria were body mass index (BMI) (ρ= 0.170, p=0.048), mean arterial pressure (MAP) (ρ= 0.280, p=0.001), glycated hemoglobin (A1c) (ρ= 0.197, p=0.022), and triglycerides (ρ= 0.219, p=0.010). After adjustment for confounding variables we found a significant and independent association between fructose intake and albuminuria (β= 13.96, p=0.006). We found a statistically significant higher albuminuria (60.8 [12.8-228.5] versus 232.2 [27.2-1273.0] mg/day, p 0.002), glycated hemoglobin (8.6±1.61 versus 9.6±2.1 %), p= 0.003, and uric acid (6.27±1.8 versus 7.2±1.5 mg/dL), p=0.012, in the group of high fructose intake versus the group with low fructose intake, and a statistically significant lower creatinine clearance (76.5±30.98 mL/min versus 94.9±36.8, p=0.014) in the group with high fructose intake versus the group with low fructose intake. In summary we found that a higher fructose intake is associated with greater albuminuria in subjects with T2DM.

• Authors: Miguel Ángel Gómez-Sámano, Paloma Almeda-Valdes, Daniel Cuevas-Ramos, María Fernanda Navarro-Flores, Héctor Donaldo Espinosa-Salazar, Mayela Martínez-Saavedra, Jefsi Argelia León-Domínguez, Víctor Manuel Enríquez-Estrada, Ana Laura López-González, Ana Laura Sarmiento-Moreno, Lucero Alejandra Rivera-González, Óscar Alfredo Juárez-León, Bernardo Pérez-González, Yessica Ávila-Palacios, Lineth Sigala-Pedroza, Eira Huerta-Ávila, María Angelina Vargas-Álvarez, Carlos Sánchez-Jaimes, Mariana Cárdenas-Vera, Roopa Mehta, Manuel Alejandro López-Flores A La Torre, Iliana Manjarrez-Martínez, Griselda Xochitl Brito-Córdova, Julia M Zuarth-Vázquez, Arturo Vega-Beyhart, Guadalupe López-Carrasco, Richard J Johnson, Francisco Javier Gómez-Pérez
• Journal: International journal of nephrology (Int J Nephrol) Vol. 2018 Pg. 5459439 ( 2018) ISSN: 2090-214X [Print] United States
• PMID: 30416829 (Publication Type: Journal Article)