Abstract | BACKGROUND: METHODS: This study was carried out on eighty-eight patients infected with HCV and twenty healthy subjects as a control. Complete blood count (CBC), aspartate aminotransferase (AST), alanine aminotransferase (ALT), antiHCV antibody, detection of HCV RNA by real-time PCR, and serum ferritin (SF) were assessed. Then API, ARR, APRI, FIB-4, and Fibro-Q were calculated. Different fibrosis stages (mild fibrosis stage (F1), moderate fibrosis stage (F2), severe fibrosis stage (F3), cirrhotic stage (F4)) were assessed using transient elastography by Fibro Scan®. RESULTS: FIB-4 index was significantly elevated (p < 0.01) with the progression of liver fibrosis at F1, F2, F3, and F4 when compared to healthy control group. The APRI score elevation between F0 and F3 and between F0 and F4 was significant (p < 0.01). SF was elevated in all fibrosis stages and significantly (p < 0.01) at F3 and F4 compared to controls. CONCLUSIONS:
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Authors | Said M Afify, Ashraf Tabll, Hend M Nawara, Mohamed El Kassas, Ashraf Elfert, Masaharu Seno, Salah El-Kousy |
Journal | Clinical laboratory
(Clin Lab)
Vol. 64
Issue 10
Pg. 1685-1693
(Oct 01 2018)
ISSN: 1433-6510 [Print] Germany |
PMID | 30336529
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Hepatitis C Antibodies
- RNA, Viral
- Ferritins
- Aspartate Aminotransferases
- Alanine Transaminase
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Topics |
- Adult
- Alanine Transaminase
(blood)
- Aspartate Aminotransferases
(blood)
- Biomarkers
(blood)
- Blood Platelets
(metabolism)
- Ferritins
(blood)
- Fibrosis
- Hepacivirus
(genetics, immunology, physiology)
- Hepatitis C Antibodies
(blood, immunology)
- Humans
- Liver
(metabolism, pathology)
- Liver Cirrhosis
(blood, diagnosis, virology)
- Middle Aged
- Platelet Count
- RNA, Viral
(blood, genetics)
- ROC Curve
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