Vitamin D deficiency is common and there exists a huge gap between recommended dietary
vitamin D intakes and the poor
vitamin D supply in the general population. While
vitamin D is important for musculoskeletal health, there are accumulating data suggesting that
vitamin D may also be important for fertility, pregnancy outcomes and lactation. Significant changes in
vitamin D metabolism during pregnancy such as increased production of the "active
vitamin D hormone"
calcitriol support the important role of
vitamin D in this setting. Observational studies show that
vitamin D deficiency is a risk marker for reduced fertility and various adverse pregnancy outcomes and is associated with a low
vitamin D content of breast milk. Meta-analyses of randomized controlled trials (RCTs) document that physiological
vitamin D supplementation during pregnancy is safe and improves
vitamin D and
calcium status, thereby protecting skeletal health. Although certain RCTs and/or meta-analyses reported some other beneficial effects, it is still not clear whether
vitamin D supplementation improves fertility or decreases the risk of adverse pregnancy outcomes such as low birth weight,
pre-eclampsia and neonatal mortality, or reduces wheeze/
asthma in the infants. Nevertheless,
vitamin D supplementation in pregnant women is frequently required to achieve a sufficient
vitamin D status as recommended by nutritional
vitamin D guidelines. In this review, we provide an overview of systematic reviews, meta-analyses and large trials reporting clinical data on the role of
vitamin D for fertility, pregnancy and lactation.