Association Between High Levels of Hepatitis B Core Antibody and Seroclearance of Hepatitis B e Antigen in Individuals With Chronic Hepatitis B Virus Infection.

Abstract

For chronic hepatitis B patients, hepatitis B e antigen (HBeAg) seroclearance signals a transition from an immunologically active phase to an inactive carrier state with a reduction in hepatitis B virus (HBV) DNA levels and a reduced risk of hepatocellular carcinoma (HCC).1 Predictors of HBeAg seroclearance include lower HBV DNA levels, viral genotype, the precore mutation, and higher serum alanine aminotransferase (ALT) levels.2.

• Authors: Jessica Liu, Hui-Han Hu, Chia-Ling Chang, Chin-Lan Jen, Mei-Hsuan Lee, Sheng-Nan Lu, Li-Yu Wang, Quan Yuan, Ning-Shao Xia, Masaya Sugiyama, Nao Nishida, Masashi Mizokami, Chien-Jen Chen, Pei-Jer Chen, Hwai-I Yang
• Journal: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association (Clin Gastroenterol Hepatol) Vol. 17 Issue 7 Pg. 1413-1415 (06 2019) ISSN: 1542-7714 [Electronic] United States
• PMID: 30267868 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2019 AGA Institute. Published by Elsevier Inc. All rights reserved.

Chemical References

• DNA, Viral
• Hepatitis B Antibodies
• Hepatitis B Surface Antigens

Topics

• DNA, Viral (analysis)
• Follow-Up Studies
• Genotype
• Hepatitis B Antibodies (immunology)
• Hepatitis B Surface Antigens (immunology)
• Hepatitis B virus (genetics, immunology)
• Hepatitis B, Chronic (metabolism, virology)
• Humans
• Immunoenzyme Techniques
• Prognosis
• Retrospective Studies
• Time Factors
• Viral Load