Antiinflammation constituents from Curcuma zedoaroides.

Abstract

Curcuma zedoaroides, a Zingiberaceae species, has been used for snake bite antidote and wound care in Thailand. Seven compounds were isolated from the bioactive chloroform extract consisted of one new guaiane sesquiterpene lactone, 5-epiphaeocaulisin A (4) and one new diarylheptanoid, 1,2,3,5-tetrahydroxy-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl) heptane (7), together with five known guaiane-type sesquiterpene lactones including gweicurculactone (1), zedoalactone B (2), phaeocaulisin C (3), zedoalactone H (5), and zedoalactone E (6). The antiinflammation was investigated on NO and TNF-α production using RAW264.7 cells. In addition, the expressions of genes involved in inflammation including iNOS, COX-2, and TNF-α were assessed. The results found that Compounds 1-7 presented their antiinflammation against NO production. The most potential effects were demonstrated on Compounds 1 and 7 with IC50 of 27.3 and 32.6 μM, respectively. Although, Compounds 1 and 7 did not inhibit TNF-α production, their suppression on iNOS and COX-2 mRNA expression were revealed. These results support the ability of chloroform fraction, Compounds 1 and 7 on antiinflammation, whereas others exhibited moderate and mild effect.

• Authors: Pattreeya Tungcharoen, Chatchai Wattanapiromsakul, Pimpimon Tansakul, Seikou Nakamura, Hisashi Matsuda, Supinya Tewtrakul
• Journal: Phytotherapy research : PTR (Phytother Res) Vol. 32 Issue 11 Pg. 2312-2320 (Nov 2018) ISSN: 1099-1573 [Electronic] England
• PMID: 30109745 (Publication Type: Journal Article)
• Copyright: © 2018 John Wiley & Sons, Ltd.

Chemical References

• Anti-Inflammatory Agents
• Azulenes
• Lactones
• Plant Extracts
• Sesquiterpenes
• Sesquiterpenes, Guaiane
• Tumor Necrosis Factor-alpha
• guaiane
• gweicurculactone
• Nitric Oxide
• Nitric Oxide Synthase Type II
• Nos2 protein, mouse
• Ptgs2 protein, mouse
• Cyclooxygenase 2

Topics

• Animals
• Anti-Inflammatory Agents (isolation & purification, pharmacology)
• Azulenes
• Curcuma (chemistry)
• Cyclooxygenase 2 (metabolism)
• Inflammation
• Lactones
• Mice
• Molecular Structure
• Nitric Oxide (metabolism)
• Nitric Oxide Synthase Type II (metabolism)
• Plant Extracts (chemistry)
• RAW 264.7 Cells
• Rhizome (chemistry)
• Sesquiterpenes
• Sesquiterpenes, Guaiane (isolation & purification, pharmacology)
• Thailand
• Tumor Necrosis Factor-alpha (metabolism)