We conducted an epidemiological study including analyses of background factors of 192 male and 13 female patients with gonorrheal
infection in the Sapporo area and at the same time, investigated the therapeutic efficacy of
sultamicillin, an
ester linked
prodrug of
ampicillin and
beta-lactamase inhibitor sulbactam in the treatment of these patients. The percentage of
infections in Sapporo was rather high in the young generation, being as high as 13.5% in teen-age boys and 30.8% in teen-age girls, which were higher than the 6.1% and 6.3% of corresponding groups in Honshu island. The source of
infections was so-called special public bath-ouse which accounted for about 31.8% of all cases which however, was lower than the 50% in Honshu island. By contrast, the percentage of their friends or so-called pick-up friends as a source of
infection in Sapporo was as high as 46.9% which was significantly higher than the 19.9% in Honshu. Juveniles who had nonprostitutes of the other sex as a source of
infection are a characteristic of the patients in Sapporo. The isolation rate of PPNG was 13.8%. The MIC (10(6) CFU/ml) of
sultamicillin ranged from 0.05 to 0.39 micrograms/ml in
beta-lactamase non-producing strains and from 0.20 to 1.56 micrograms/ml in
beta-lactamase producing strains showing no trend of higher MIC against
beta-lactamase producing strains. There was almost no difference in the efficacy of
sultamicillin between a daily dose of 750 mg (2
tablets) and 1125 mg (3
tablets) nor in side effects. The eradication rate (efficacy rate) of gonococcus following a 3-day
therapy was 96.2% (38.9% excellent cure rate) in male patients and 83.3% (8.3%) in female patients. In 31% of the male patients who underwent a 7-day
therapy, residual serous secretion was found though some inaccuracy is involved in this data since dropouts were not counted. This suggests the need of concurrent
therapy with other appropriate drugs in consideration of possible
mixed infection involving Chlamydia trachomatis or other microorganisms.