Sulbactam

A beta-lactamase inhibitor with very weak antibacterial action. The compound prevents antibiotic destruction of beta-lactam antibiotics by inhibiting beta-lactamases, thus extending their spectrum activity. Combinations of sulbactam with beta-lactam antibiotics have been used successfully for the therapy of infections caused by organisms resistant to the antibiotic alone.

Also Known As:

Networked: 460 relevant articles (106 outcomes, 96 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Kohno, Shigeru: 5 articles (03/2015 - 01/2006)
2.	Bantar, C: 4 articles (06/2009 - 06/2000)
3.	Soutric, J: 4 articles (12/2002 - 06/2000)
4.	Yanagihara, Katsunori: 3 articles (12/2013 - 01/2006)
5.	Kara, Ateş: 3 articles (05/2011 - 10/2005)
6.	Falagas, Matthew E: 3 articles (04/2010 - 01/2007)
7.	Pachón, Jerónimo: 3 articles (03/2010 - 09/2006)
8.	Arenoso, H J: 3 articles (06/2009 - 06/2000)
9.	Fernandez Canigia, L: 3 articles (06/2009 - 06/2000)
10.	Juránková, J: 3 articles (12/2007 - 10/2003)

Related Diseases

1.	Infection 04/01/2014 - "The data obtained in this study should be supported by further advanced in vitro and clinical studies to predict the accurate clinical efficacy of sulbactam containing combinations on A.baumannii infections. " 04/01/2001 - "These results show the efficacy of sulbactam in infections caused by susceptible strains of A. " 03/01/1990 - "Efficacy of sulbactam in an in vitro model of mixed aerobic/anaerobic infections." 04/01/2015 - "Population pharmacokinetic-pharmacodynamic target attainment analysis of sulbactam in patients with impaired renal function: dosing considerations for Acinetobacter baumannii infections." 07/01/2014 - "It has been found that sulbactam alone may be used to treat infections caused by A. "
2.	Pneumonia (Pneumonitis) 06/01/2015 - "Sulbactam treatment for pneumonia involving multidrug-resistant Acinetobacter calcoaceticus-Acinetobacter baumannii complex." 12/01/2002 - "Chemother 2000; 12: 223-227) to assess the efficacy of amoxicillin/sulbactam (875 mg/125 mg), given orally twice-a-day for 7 days in the treatment of patients with community-acquired pneumonia (CAP). " 12/01/2002 - "Efficacy of amoxicillin-sulbactam, given twice-a-day, for the treatment of community-acquired pneumonia: a clinical trial based on a pharmacodynamic model." 12/01/1987 - "Efficacy of sulbactam-ampicillin in an induced Pasteurella haemolytica pneumonia model in calves." 03/01/2015 - "Efficacy and safety of intravenous sulbactam/ampicillin 3 g 4 times daily in Japanese adults with moderate to severe community-acquired pneumonia: a multicenter, open-label, uncontrolled study."
3.	Respiratory Tract Infections (Respiratory Tract Infection) 01/01/1988 - "A review of these studies indicates that therapy with sulbactam/ampicillin effectively treats lower respiratory tract infections in severely ill patients without causing serious adverse reactions." 07/01/1996 - "[Efficacy of sulbactam/cefoperazone in respiratory tract infections in elderly patients with underlying respiratory diseases]." 07/01/1995 - "[Clinical efficacy of sulbactam/cefoperazone for the treatment of geriatric patients with respiratory tract infections]." 10/01/1991 - "Clinical efficacy: in subjects with lower respiratory tract infections, sulbactam/ampicillin cured 32 patients (72.72%) and ameliorated the clinical status of 8 patients (18.18%); efficacy rate: 90.9%).(ABSTRACT TRUNCATED AT 250 WORDS)" 08/01/2001 - "This study suggests that amoxicillin/sulbactam (500mg/500mg) is still a suitable option for treating community-acquired lower respiratory tract infections, allowing a b.i.d. "
4.	Endocarditis 09/01/1993 - "Efficacy of cefoperazone in combination with sulbactam in experimental Staphylococcus aureus endocarditis in rabbits." 01/01/2005 - "The antibacterial therapy with cefoperazone/sulbactam in 9 patients was performed during the operation because of active infectious endocarditis. " 04/01/2001 - "In the endocarditis model, imipenem (t > MIC, 2.12 h) was more efficacious than sulbactam (t > MIC, 1.17 h) in bacterial clearance from vegetations. " 11/01/1990 - "A marked inoculum effect was demonstrated with sulbactam: effective concentrations of inhibitor needed to reduce the MIC and MBC of ceftriaxone to similar levels increased from 1 microgram/ml in the presence of an inoculum of 5 x 10(5) CFU/ml to 20 micrograms/ml in the presence of an inoculum of 1 x 10(7) CFU/ml. In vivo, sulbactam given at 200 mg/kg of body weight every 12 h, a dosage higher than that previously reported to be effective against rabbit endocarditis caused by other microorganisms, was not sufficient to restore the complete activity of ceftriaxone given at 30 mg/kg once daily for 4 days. " 04/01/2001 - "Sulbactam and imipenem were compared in an experimental pneumonia model in immunocompetent mice, using a susceptible strain of Acinetobacter baumannii, and in an experimental endocarditis model in rabbits, using an intermediately susceptible strain. "
5.	Bacterial Infections (Bacterial Infection) 11/01/1986 - "The data support the intravenous administration of 12.5-25 mg of sulbactam/kg every 6 to 8 hr for assessing the adequacy of this drug as an adjunct to beta-lactam therapy for various bacterial infections in children." 04/01/1989 - "Clinical efficacy of sulbactam/ampicillin in the treatment of moderately severe bacterial infections." 06/01/1996 - "These studies have established the key role of sulbactam/ampicillin in the treatment of a wide variety of bacterial infections." 10/01/1984 - "[Clinical studies of sulbactam/cefoperazone therapy in pediatric bacterial infections]." 01/01/2008 - "Cefoperazone and sulbactam are prescribed in combination and used in the treatment of moderate to severe bacterial infections. "

Related Drugs and Biologics

1.	Ampicillin (Omnipen)
2.	Cefoperazone (Cefoperazone Sodium)
3.	beta-Lactamases (beta-Lactamase)
4.	Clindamycin (Cleocin)
5.	Colistin (Coly-Mycin)
6.	Piperacillin
7.	Imipenem
8.	Gentamicins (Gentamicin)
9.	sultamicillin (ampicillin-sulbactam)
10.	tazobactam

Related Therapies and Procedures

1.	Anesthesia
2.	Vacuum Curettage (Vacuum Pump)
3.	Choledochostomy
4.	Aftercare (After-Treatment)
5.	Cesarean Section (Caesarean Section)