Abstract | AIMS/INTRODUCTION: MATERIALS AND METHODS: Male C57BL/6 mice were induced with a high-fat diet for 12 weeks, followed by a 4-week treatment of HGF or vehicle saline. The levels of fasting blood glucose, fasting insulin and homeostatic model assessment of insulin resistance were calculated for insulin sensitivity. Biochemical plasma parameters were also measured to assess the effect of HGF on lipid accumulation. Additionally, genes in the lipid metabolism pathway were evaluated in palmitic acid-treated HepG2 cells and high-fat diet mice. RESULTS: CONCLUSIONS: HGF treatment can ameliorate hepatic insulin resistance and steatosis through regulation of lipid metabolism. These effects might occur through farnesoid X receptor-small heterodimer partner axis-dependent transcriptional activity.
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Authors | Yali Jing, Qingmin Sun, Xiaolu Xiong, Ran Meng, Sunyinyan Tang, Shu Cao, Yan Bi, Dalong Zhu |
Journal | Journal of diabetes investigation
(J Diabetes Investig)
Vol. 10
Issue 2
Pg. 251-260
(Mar 2019)
ISSN: 2040-1124 [Electronic] Japan |
PMID | 30070033
(Publication Type: Journal Article)
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Copyright | © 2018 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. |
Chemical References |
- Blood Glucose
- Hepatocyte Growth Factor
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Topics |
- Animals
- Blood Glucose
(analysis)
- Body Weight
(drug effects)
- Diet, High-Fat
- Hep G2 Cells
- Hepatocyte Growth Factor
(pharmacology)
- Humans
- Insulin Resistance
- Lipid Metabolism
(drug effects)
- Liver
(drug effects, metabolism, pathology)
- Male
- Mice
- Mice, Inbred C57BL
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