HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Advances in IgG4-related pancreatobiliary diseases.

Abstract
Autoimmune pancreatitis is an unusual form of pancreatitis that is histologically characterised by a massive infiltration of lymphocytes and IgG4-positive plasma cells and storiform fibrosis. The disease is recognised as a pancreatic manifestation of IgG4-related disease. IgG4-related sclerosing cholangitis is a biliary counterpart that is typically associated with autoimmune pancreatitis. Two parallel immunological responses are thought to underlie the pathophysiology of these diseases: a pro-inflammatory, tissue-destructive process and an anti-inflammatory feedback response, which probably relates to IgG4 production. These diseases should be differentiated from conditions with a similar presentation (eg, pancreatobiliary malignancy, primary sclerosing cholangitis) by comparison of serum IgG4 concentration, imaging features, other organ involvement, histology, and steroid responsiveness. Corticosteroids are first-line drugs, although rituximab has been shown to effectively deplete B cells in IgG4-related disease. Although the risk of relapse is high, no standardised treatment protocol exists for relapsed cases.
AuthorsTerumi Kamisawa, Yoh Zen, Takahiro Nakazawa, Kazuichi Okazaki
JournalThe lancet. Gastroenterology & hepatology (Lancet Gastroenterol Hepatol) Vol. 3 Issue 8 Pg. 575-585 (08 2018) ISSN: 2468-1253 [Electronic] Netherlands
PMID30047448 (Publication Type: Journal Article, Review)
CopyrightCopyright © 2018 Elsevier Ltd. All rights reserved.
Chemical References
  • Adrenal Cortex Hormones
  • Immunologic Factors
  • Rituximab
Topics
  • Adrenal Cortex Hormones (therapeutic use)
  • Cholangitis, Sclerosing (drug therapy, epidemiology, immunology, pathology)
  • Humans
  • Immunoglobulin G4-Related Disease (drug therapy, epidemiology, immunology, pathology)
  • Immunologic Factors (therapeutic use)
  • Incidence
  • Pancreatitis (drug therapy, epidemiology, immunology, pathology)
  • Prevalence
  • Recurrence
  • Remission Induction
  • Rituximab (therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: