Abstract |
Alzheimer's disease (AD) is the most common form of dementia among older people. Although soluble amyloid species are recognized triggers of the disease, no therapeutic approach is able to stop it. 6-(Methylsulfinyl)hexyl isothiocyanate (6-MSITC) is a major bioactive compound in Wasabia japonica, which is a typical Japanese pungent spice. Recently, in vivo and in vitro studies demonstrated that 6-MSITC has several biological properties. The aim of the present study was to investigate the neuroprotective activity of 6-MSITC in a murine AD model, induced by intracerebroventricular injection of β- amyloid oligomers (Aβ1-42O). The treatment with 6-MSITC started 1 h after the surgery for the next 10 days. Behavioral analysis showed that 6-MSITC ameliorated Aβ1-42O-induced memory impairments. The decrease of glutathione levels and increase of reactive oxygen species in hippocampal tissues following Aβ1-42O injection were reduced by 6-MSITC. Moreover, activation of caspases, increase of inflammatory factors, and phosphorylation of ERK and GSK3 were inhibited by 6-MSITC. These results highlighted an interesting neuroprotective activity of 6-MSITC, which was able to restore a physiological oxidative status, interfere positively with Nrf2-pathway, decrease apoptosis and neuroinflammation and contribute to behavioral recovery. Taken together, these findings demonstrated that 6-MSITC could be a promising complement for AD therapy.
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Authors | Fabiana Morroni, Giulia Sita, Agnese Graziosi, Eleonora Turrini, Carmela Fimognari, Andrea Tarozzi, Patrizia Hrelia |
Journal | International journal of molecular sciences
(Int J Mol Sci)
Vol. 19
Issue 7
(Jul 18 2018)
ISSN: 1422-0067 [Electronic] Switzerland |
PMID | 30021941
(Publication Type: Journal Article)
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Chemical References |
- 6-(Methylsulfinyl)hexyl isothiocyanate
- Amyloid beta-Peptides
- Isothiocyanates
- Neuroprotective Agents
- Glycogen Synthase Kinase 3 beta
- Extracellular Signal-Regulated MAP Kinases
- Caspases
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Topics |
- Amyloid beta-Peptides
(toxicity)
- Animals
- Apoptosis
(drug effects)
- Caspases
(metabolism)
- Cell Death
(drug effects)
- Cognition Disorders
(complications, drug therapy, pathology)
- Extracellular Signal-Regulated MAP Kinases
(metabolism)
- Glycogen Synthase Kinase 3 beta
(metabolism)
- Hippocampus
(drug effects, pathology)
- Inflammation
(complications, drug therapy, pathology)
- Isothiocyanates
(chemistry, pharmacology, therapeutic use)
- Mice
- Neurons
(drug effects, metabolism, pathology)
- Neuroprotective Agents
(chemistry, pharmacology, therapeutic use)
- Oxidation-Reduction
- Oxidative Stress
(drug effects)
- Phosphorylation
(drug effects)
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