Can the frequency of myocardial infarction be reduced during coronary artery operations.

Abstract

A prospective experiment was carried out in 56 patients undergoing coronary artery revascularization to determine whether those having a glucose-insulin-potassium (GIK) perfusion during the procedure would have fewer myocardial infarctions (MI) compared with patients given a control perfusion of Normosol-R. Six patients (11%) developed an MI, defined as a 24-hour creatine phosphokinase MB isoenzyme value of 100 IU per liter or greater. Four (13%) had control perfusions and 2(8%) had GIK perfusion. One MI in a double-graft recipient who had GIK perfusion occurred because of a technical surgical error; therefore, the corrected MI rate was 13% in control patients compared with 4% for the GIK group. These data, as well as the more frequent spontaneous defibrillation in patients who had GIK perfusion, suggest that GIK was of benefit.

• Authors: J F Ray 3rd, D A Tewksbury, W O Myers, F J Wenzel, R D Sautter
• Journal: The Annals of thoracic surgery (Ann Thorac Surg) Vol. 23 Pg. 14-9 (Jan 1977) ISSN: 0003-4975 [Print] Netherlands
• PMID: 299803 (Publication Type: Journal Article)

Chemical References

• Blood Glucose
• Insulin
• Glucose
• Potassium

Topics

• Blood Glucose (metabolism)
• Coronary Artery Bypass
• Coronary Vessels (surgery)
• Glucose (administration & dosage)
• Humans
• Insulin (administration & dosage, blood)
• Myocardial Infarction (prevention & control)
• Perfusion
• Potassium (administration & dosage, blood)
• Time Factors