Abstract | BACKGROUND:
Wogonin is commonly used for the treatment of allergic diseases. However, neither its precise effect in preventing allergic rhinitis (AR) nor its mechanism of action are known. OBJECTIVES: In this study, the effect of wogonin on allergic responses in ovalbumin (OVA) induced AR was investigated in mice. METHODS: BALB/c mice were sensitized with intraperitoneal (i.p.) OVA and then challenged intranasally with OVA. Wogonin (10 and 30 mg/kg) was given to the treatment groups, and the effect of wogonin on the release of allergic inflammatory mediators, specifically OVA-specific immunoglobulin E ( IgE) and inflammatory cytokines, was explored. Eosinophil infiltration and the levels of interleukin (IL) 5 and IL-13 were measured by immunohistochemistry. RESULTS: In mice with AR, wogonin decreased OVA-specific IgE levels in serum, and the levels of the cytokines IL-4, IL-5, IL-13, eotaxin, and RANTES in nasal lavage fluid. Serum levels of IL-4, IL-5, and IL-13 were lower in both groups of wogonin-pretreated mice than in the OVA group. A reduction in eosinophil infiltration of the nasal mucosa and inhibition of the expression of IL-5 and IL-13 were also noted in the treated groups. CONCLUSION:
Wogonin induced antiallergic effects in a murine model of AR by decreasing the infiltration of eosinophils and levels of T-helper type 2 cytokines. Thus, wogonin merits consideration as a therapeutic agent for treating AR.
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Authors | Kyeong Ah Kim, Joo Hyun Jung, Yun Sook Choi, Gyu Kang, Seon Tae Kim |
Journal | Allergy & rhinology (Providence, R.I.)
(Allergy Rhinol (Providence))
2018 Jan-Dec
Vol. 9
Pg. 2152656718764145
ISSN: 2152-6575 [Print] United States |
PMID | 29977652
(Publication Type: Journal Article)
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