Abstract | BACKGROUND: METHODS AND RESULTS: In this 4-month, double-blind, randomized controlled trial comprising 96 untreated patients, 27 women and 58 men, aged 31 to 70 years, completed the study. The active group received individually made adjustable mandibular advancement devices, and the control group was given individually made sham devices, to be used during sleep. Polysomnographic sleep recordings and ambulatory 24-hour blood pressure measurements were performed at baseline and at follow-up. In women with mandibular advancement devices, the mean nighttime systolic blood pressure was 10.8 mm Hg (95% confidence interval, 4.0-17.7 mm Hg; P=0.004) lower than in the women in the sham group, adjusted for baseline blood pressure, age, body mass index, and the apnea-hypopnea index. The mean nighttime adjusted diastolic blood pressure was 6.6 mm Hg (95% confidence interval, 2.7-10.4 mm Hg; P=0.002) lower in the mandibular advancement device group. In men, there were no significant differences in blood pressure at night or during the daytime between the intervention groups. CONCLUSIONS: CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov. Unique identifier: NCT00477009.
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Authors | Helene Rietz, Karl A Franklin, Bo Carlberg, Carin Sahlin, Marie Marklund |
Journal | Journal of the American Heart Association
(J Am Heart Assoc)
Vol. 7
Issue 13
(06 21 2018)
ISSN: 2047-9980 [Electronic] England |
PMID | 29929990
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | © 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. |
Topics |
- Adult
- Aged
- Blood Pressure
- Circadian Rhythm
- Double-Blind Method
- Equipment Design
- Female
- Humans
- Hypertension
(diagnosis, etiology, physiopathology)
- Male
- Mandibular Advancement
(instrumentation)
- Middle Aged
- Severity of Illness Index
- Sex Factors
- Sleep Apnea Syndromes
(complications, diagnosis, physiopathology, therapy)
- Time Factors
- Treatment Outcome
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