Abstract | INTRODUCTION: METHODS: Thirty-two nude athymic mice received intraperitoneal injections of paclitaxel (20 mg/kg), SAHA (25 mg/kg), paclitaxel + SAHA (20 mg/kg + 25 mg/kg), or no treatment for 2 weeks prior to surgery. Under general anesthesia, 8-mm full-thickness dorsal wounds were created in all animals, and a silicone splint was attached to minimize wound contraction. The wounds were measured twice a week with a surgical caliper until healing was complete. To evaluate the in vivo effect of drug treatment, 16 athymic nude mice with MDA-MB-231 xenografts received the treatments described previously, following which tumor volumes were compared between groups. RESULTS: Average wound healing time was prolonged in mice treated with paclitaxel (20 ± 1.9 days), and combination SAHA + paclitaxel therapy improved average wound healing time (17.0 ± 1.8 days). In the xenograft model, the antitumor effect of SAHA and paclitaxel (average tumor volume 43.9 ± 34.1 mm) was greater than paclitaxel alone (105.8 ± 73.8 mm). CONCLUSIONS:
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Authors | Joseph H Marcotte, Deviney A Rattigan, Robin F Irons, Kevin W Cahill, Ping Zhang, Shaohua Chang, Kiavash R Koko, John P Gaughan, Jeffrey P Carpenter, Spencer A Brown, Tulin Budak-Alpdogan |
Journal | Annals of plastic surgery
(Ann Plast Surg)
Vol. 81
Issue 4
Pg. 482-486
(10 2018)
ISSN: 1536-3708 [Electronic] United States |
PMID | 29905606
(Publication Type: Journal Article)
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Chemical References |
- Histone Deacetylase Inhibitors
- Vorinostat
- Paclitaxel
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Topics |
- Animals
- Back Injuries
(drug therapy)
- Disease Models, Animal
- Histone Deacetylase Inhibitors
(pharmacology)
- Mice
- Mice, Nude
- Paclitaxel
(pharmacology)
- Vorinostat
(pharmacology)
- Wound Healing
(drug effects)
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