Antibacterial, anticancer and antioxidant potential of silver nanoparticles engineered using Trigonella foenum-graecum seed extract.

Abstract

In this study, the authors report a simple and eco-friendly method for the synthesis of silver nanoparticles (AgNPs) using Trigonella foenum-graecum (TFG) seed extract. They explored several parameters dictating the biosynthesis of TFG-AgNPs such as reaction time, temperature, concentration of AgNO3, and TFG extract amount. Physicochemical characterisation of TFG-AgNPs was done on dynamic light scattering (DLS), field emission electron microscopy, energy dispersive X-ray spectroscopy, X-ray diffraction and Fourier transform infrared spectroscopy. The size determination studies using DLS revealed of TFG-AgNPs size between 95 and 110 nm. The antibacterial activity was studied against Escherichia coli, Proteus vulgaris, Pseudomonas aeruginosa and Staphylococcus aureus. The biosynthesised TFG-AgNPs showed remarkable anticancer efficacy against skin cancer cell line, A431 and also exhibited significant antioxidant efficacy.

• Authors: Shivangi Goyal, Nidhi Gupta, Ajeet Kumar, Sreemoyee Chatterjee, Surendra Nimesh
• Journal: IET nanobiotechnology (IET Nanobiotechnol) Vol. 12 Issue 4 Pg. 526-533 (Jun 2018) ISSN: 1751-8741 [Print] United States
• PMID: 29768242 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Antineoplastic Agents
• Antioxidants
• Biphenyl Compounds
• Picrates
• Plant Extracts
• Silver
• 1,1-diphenyl-2-picrylhydrazyl

Topics

• Anti-Bacterial Agents (chemistry, pharmacology)
• Antineoplastic Agents (chemistry, pharmacology)
• Antioxidants (chemistry, pharmacology)
• Biphenyl Compounds
• Cell Line, Tumor
• Cell Survival
• Green Chemistry Technology
• Humans
• Metal Nanoparticles (chemistry)
• Particle Size
• Picrates
• Plant Extracts (chemistry, metabolism, pharmacology)
• Seeds (chemistry, metabolism)
• Silver (chemistry, pharmacology)
• Spectroscopy, Fourier Transform Infrared
• Trigonella (chemistry)