Abstract | BACKGROUND: METHODS: Using the Taiwan National Health Insurance Research Database, we enrolled 35,949 adolescents and young adults with ADHD (ICD-9-CM code: 314) and 71,898 (1:2) age- and sex-matched controls from 2002 through 2009 and followed up with them until the end of 2011. Participants who developed type 2 DM during the follow-up period were identified. RESULTS: Adolescents (hazard ratio [HR] = 2.83; 95% CI, 1.96-4.09) and young adults (HR = 3.28; 95% CI, 1.41-7.63) with ADHD had a higher risk of developing type 2 DM than did the controls after adjustment for demographic characteristics, use of ADHD medications and atypical antipsychotics, and medical comorbidities. Individuals with ADHD had a shorter mean ± SD duration between enrollment and onset of type 2 DM (3.17 ± 2.33 vs 4.08 ± 2.11 years, P = .004) during the follow-up compared with the controls. Sensitivity analyses after excluding first-year (HR = 2.36; 95% CI, 1.65-3.38) and first-3-year (HR = 1.92; 95% CI, 1.19-3.09) observation periods were consistent. Long-term use of atypical antipsychotics was associated with a higher likelihood of subsequent type 2 DM (HR = 2.82, 95% CI, 1.74-4.58). DISCUSSION: Adolescents and young adults with ADHD were more likely than non- ADHD controls to develop type 2 DM in later life. In addition, those with ADHD taking atypical antipsychotics exhibited a higher risk. Although correlation does not equal causation, our findings merit further study about the relationship between ADHD and type 2 DM.
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Authors | Mu-Hong Chen, Tai-Long Pan, Ju-Wei Hsu, Kai-Lin Huang, Tung-Ping Su, Cheng-Ta Li, Wei-Chen Lin, Shih-Jen Tsai, Wen-Han Chang, Tzeng-Ji Chen, Ya-Mei Bai |
Journal | The Journal of clinical psychiatry
(J Clin Psychiatry)
2018 May/Jun
Vol. 79
Issue 3
ISSN: 1555-2101 [Electronic] United States |
PMID | 29727071
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © Copyright 2018 Physicians Postgraduate Press, Inc. |
Chemical References |
- Adrenergic Uptake Inhibitors
- Antipsychotic Agents
- Central Nervous System Stimulants
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Topics |
- Adolescent
- Adrenergic Uptake Inhibitors
(therapeutic use)
- Adult
- Antipsychotic Agents
(therapeutic use)
- Attention Deficit Disorder with Hyperactivity
(drug therapy, epidemiology)
- Central Nervous System Stimulants
(therapeutic use)
- Child
- Comorbidity
- Diabetes Mellitus, Type 2
(epidemiology)
- Female
- Follow-Up Studies
- Humans
- Longitudinal Studies
- Male
- National Health Programs
(statistics & numerical data)
- Prevalence
- Risk
- Taiwan
(epidemiology)
- Young Adult
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