[Testosterone Undecanoate Pills improves insulin resistance in type-2 diabetes men with hypogonadism].

Abstract

OBJECTIVE:

To evaluate the effects of Testosterone Undecanoate Pills (TUP) on insulin resistance (IR) in type-2 diabetes men with hypogonadism.

METHODS:

We randomly divided 82 type-2 diabetes patients with hypogonadism into a treatment (n = 42) and a control group (n = 40), both maintaining their glucose- and lipid-reducing therapies, while the former treated orally with TUP in addition. After 6 months of medication, we compared the body mass index (BMI), waist circumference (WC), blood glucose level, HbA1c, lipid profile, IR index obtained by homeostatic model assessment (HOMA-IR), insulin sensitivity index (ISI), sex hormone levels, and sexual function scores between the two groups of patients.

RESULTS:

Compared with the baseline, the patients in the treatment group showed significant decreases after medication in BMI (［26.71 ± 2.39］ vs ［25.15 ± 2.28］ kg/m2, P <0.05), WC (［89.96 ± 9.13］ vs ［85.03 ± 9.58］ cm, P <0.05), HbA1C (［7.73 ± 1.31］ vs ［7.01 ± 1.25］ %, P <0.05), and triglyeride (［1.97 ± 0.83］ vs ［1.41 ± 0.69］ mmol/L, P <0.05), a markedly elevated level of total testosterone (［7.16 ± 2.21］ vs ［14.22 ± 2.63］ nmol/L, P <0.05), and remarkable improvement in HOMA-IR (3.76 ± 1.18 vs 2.55 ± 1.03, P <0.05), ISI (96 ± 51 vs 138 ± 53, P <0.05) and total scores of the Aging Males' Symptoms (P <0.05). But no significant changes were observed in the scores of the International Index of Erectile Function (IIEF) after treatment (13.28 ± 6.38 vs 14.95 ± 6.08, P >0.05).

CONCLUSIONS:

TUP can significantly improve insulin resistance in type-2 diabetes men with hypogonadism.

• Authors: Hong-Jie DI, Yao-Fu Fan, Hui-Feng Zhang, Ke-Mian Liu, Chao Liu
• Journal: Zhonghua nan ke xue = National journal of andrology (Zhonghua Nan Ke Xue) Vol. 23 Issue 6 Pg. 517-521 (Jun 2017) ISSN: 1009-3591 [Print] China
• PMID: 29722943 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Androgens
• Blood Glucose
• Glycated Hemoglobin A
• Lipids
• hemoglobin A1c protein, human
• Testosterone
• testosterone undecanoate

Topics

• Androgens (administration & dosage, therapeutic use)
• Blood Glucose (analysis)
• Body Mass Index
• Diabetes Mellitus, Type 2 (blood, complications, drug therapy)
• Glycated Hemoglobin (analysis)
• Humans
• Hypogonadism (blood, drug therapy)
• Insulin Resistance
• Lipids (blood)
• Male
• Testosterone (administration & dosage, analogs & derivatives, therapeutic use)
• Waist Circumference