Management of Crohn's Disease and Complications in Patients With Ostomies.

Abstract

Fecal diversion with ostomy construction can be a temporary or definitive surgical measure for the treatment of refractory inflammatory bowel disease (IBD). However, the fecal diversion surgery is associated with various stoma, peristomal complications, and recurrence or occurrence of de novo small bowel Crohn's disease (CD). Stoma complications often need enterostomal therapy or surgical revision. Peristomal cutaneous lesions, such as pyoderma gangrenosum, usually require immunomodulator or biological therapy. Routine monitoring for occurrence or recurrence of CD with endoscopy or imaging should be performed, and prophylaxis with mesalamines, antibiotics, immunomodulators, or anti-TNFα or anti-integrin agents is needed for patients at risk. Those agents, along with corticosteroids, may also be used for the treatment of CD of the neo-small intestine, particularly inflammatory and fistulizing phenotypes. Endoscopic balloon dilation or endoscopic stricturotomy via stoma is safe and feasible to treat short (<4-5 cm), straight strictures in the neo-small intestine. Medically or endoscopically refractory fibrostenotic disease usually requires surgical intervention, with bowel-sparing stricturoplasty being the surgical treatment of choice.

• Authors: Xinying Wang, Bo Shen
• Journal: Inflammatory bowel diseases (Inflamm Bowel Dis) Vol. 24 Issue 6 Pg. 1167-1184 (05 18 2018) ISSN: 1536-4844 [Electronic] England
• PMID: 29722891 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Topics

• Catheterization
• Constriction, Pathologic (drug therapy, surgery)
• Crohn Disease (drug therapy, pathology, surgery)
• Dilatation
• Endoscopy, Gastrointestinal
• Humans
• Intestines (pathology, surgery)
• Ostomy
• Pyoderma Gangrenosum (etiology)
• Recurrence
• Reoperation
• Severity of Illness Index
• Surgical Stomas (pathology)
• Treatment Outcome