Abstract | Background: Little is known about the effect of hepatitis C virus (HCV) infection on gut microbiota and the relationship between alteration of gut microbiota and chronic hepatitis C (CHC) progression. We performed a comparative study of gut microbiota composition between CHC patients and healthy individuals. Methods: Results: Compared with healthy individuals, bacterial diversity was lower in persons with HCV infection, with a decrease in the order Clostridiales and an increase in Streptococcus and Lactobacillus. Microbiota dysbiosis already appeared in the PNALT stage with the transient increase in Bacteroides and Enterobacteriaceae. Predicted metagenomics of microbial communities showed an increase in the urease gene mainly encoded by viridans streptococci during CHC progression, consistent with a significantly higher fecal pH in CH and LC patients than in healthy individuals or those in the PNALT stage. Conclusions: HCV infection is associated with gut dysbiosis, even in patients with mild liver disease. Additionally, overgrowth of viridans streptococci can account for hyperammonemia in CH and LC. Further studies would help to propose a novel treatment strategy because the gut microbiome can be therapeutically altered, potentially reducing the complications of chronic liver disease.
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Authors | Takako Inoue, Jiro Nakayama, Kei Moriya, Hideto Kawaratani, Rie Momoda, Kiyoaki Ito, Etsuko Iio, Shunsuke Nojiri, Kei Fujiwara, Masashi Yoneda, Hitoshi Yoshiji, Yasuhito Tanaka |
Journal | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
(Clin Infect Dis)
Vol. 67
Issue 6
Pg. 869-877
(08 31 2018)
ISSN: 1537-6591 [Electronic] United States |
PMID | 29718124
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- DNA, Bacterial
- RNA, Ribosomal, 16S
- Alanine Transaminase
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Topics |
- Aged
- Aged, 80 and over
- Alanine Transaminase
(blood)
- Bacteria
(classification, isolation & purification)
- Case-Control Studies
- DNA, Bacterial
(genetics)
- Disease Progression
- Dysbiosis
(virology)
- Feces
(microbiology)
- Female
- Gastrointestinal Microbiome
- Hepacivirus
(isolation & purification)
- Hepatitis C, Chronic
(complications)
- High-Throughput Nucleotide Sequencing
- Humans
- Male
- Metagenomics
- Middle Aged
- RNA, Ribosomal, 16S
(genetics)
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