Hyperammonemia

05/01/2001 - "An improved understanding of the metabolism of ammonia and neurological consequences of hyperammonemia will assist the nephrologist in providing optimal care for this high-risk patient population."
10/26/2019 - "If hyperammonemia is the primary cause of generalized convulsion, the serum ammonia concentration will remain high until the cause is eliminated. "
11/01/2021 - "LT was effective for long-term survival, prevented recurrent hyperammonemia attack, and lowered baseline blood ammonia levels in patients with UCDs. "
01/28/2018 - "In this review, we discuss the significance of hyperammonemia and its related diseases and the efficacy of the current management methods for hyperammonemia to understand the mechanism of ammonia transport in the human body. "
05/01/2023 - "Further studies are required to determine the benefit of routine ammonia level monitoring and to guide the management of VPA-associated hyperammonemia."

06/21/1984 - "Successful therapy of episodic hyperammonemia plays an important part in the long-term management of disorders of the urea cycle."
05/01/2005 - "To investigate the incidences of urea cycle defects (UCDs) in the patients with hyperammonemia and study their etiology, clinical and laboratory features. "
06/08/2023 - "The first is the development of hyperammonemia, as the liver can no longer synthesize urea. "
01/01/2022 - "In silico analysis revealed a possible differential affinity between wild-type and mutant OTCase, while Arg92Gln decreases the binding ability of OTCase to the substrate, which can disrupt the urea cycle and explains the molecular pathogenicity of clinical hyperammonemia. "
01/01/2022 - "However, in response to severe metabolic stress with attendant increased requirements on urea cycle function, the impaired promoter function results in inadequate OTC expression with resultant hyperammonemia. "

03/01/2017 - "The serum carnitine concentration rose with levocarnitine supplementation, reaching steady state after 1 month and, in parallel, refractory hyperammonemia was significantly improved. "
11/01/2020 - "We also report that treatment with carnitine improved hyperammonemia, allowing the continuation of STP."
09/01/2009 - "This study aimed to evaluate the risk frequency of hyperammonemia and abnormal carnitine levels in children receiving VPA who were otherwise free of neurological or obvious nutritional problems. "
04/01/2001 - "Production criteria were not affected by inclusion of L-carnitine in the diet, however, L-carnitine reduced experimentally induced hyperammonemia by day 50 of the trial."
11/01/2022 - "We describe the case of a 56-year-old man who presented to the emergency department after an intentional VPA overdose, was found to have hyperammonemia, and was treated with L-carnitine exclusively. "

01/01/2022 - "Rifaximin was thus significantly effective against both hyperammonemia and CHE in Japanese patients."
01/01/2021 - "Prophylactic use of rifaximin for 12 weeks improved hyperammonemia and neurophysiological function, maintained gut microbiota diversity, composition and did not change the overall resistome. "
12/21/2017 - "Treatment with rifaximin for 4 wk improved hyperammonemia (from 90.6 ± 23.9 μg/dL to 73.1 ± 33.1 μg/dL; P < 0.05) and time required for NCT (from 68.2 ± 17.4 s to 54.9 ± 20.3 s; P < 0.05) in patients who had higher levels at baseline. "
01/01/2022 - "We aimed to investigate the efficacy of rifaximin against hyperammonemia and CHE in Japan. "
01/01/2021 - "Rifaximin improved hyperammonemia and cognitive function in the 21 patients who completed rifaximin treatment. "

05/01/1983 - "Although sodium benzoate offers considerable promise for the treatment of hyperammonemia, toxicity appears likely in some infants receiving this drug in currently recommended doses. "
01/07/1993 - "Effect of sodium benzoate on cerebral and hepatic energy metabolites in spf mice with congenital hyperammonemia."
12/01/1989 - "It is recommended that methylsuccinate-free sodium benzoate should be used for the treatment of hyperammonemia."
12/01/1989 - "Of the two unusual substances, methylsuccinate was found to be a contaminant of sodium benzoate administered for the treatment of hyperammonemia. "
10/01/1988 - "Our results warrant a reevaluation of the use of sodium benzoate in the treatment of hyperammonemia."

01/01/2011 - "Open questions remain which concern the optimal dosage in acute and long-term use of N-carbamyl-L-glutamate and potential additional disorders in which the drug might also be effective in treating acute hyperammonemia. "
01/01/2017 - "molmol on glutamate-NO-cGMP and Nrf2/ARE/HO-1 pathways in hyperammonemia. "
07/01/2009 - "Impairment of astrocytic glutamate uptake is another important feature of HE and hyperammonemia. "
08/01/2005 - "Neonatal hyperammonemia: the N-carbamoyl-L-glutamic acid test."
08/01/2002 - "Hyperammonemia could induce the formation of inducible NOS in astroglial cells, with the consequent NO formation, deactivation of GS and dawn-regulation of glutamate uptake. "

01/01/1980 - "At this level hyperammonemia may result from overtreatment, but this can be quickly cleared by a small dose of arginine. "
04/01/1985 - "Therefore, selected animals fed an arginine-deficient diet may serve as a useful model for the study of chronic hyperammonemia. "
08/29/2019 - "Arginine levels remained high after surgery; however, hyperammonemia did not develop. "
11/16/2015 - "Arginine deficiency will result in hyperammonemia, which may be fatal. "
09/01/2006 - "Arginine treatment is able to reduces attacks of hyperammonemia in boys with late-onset OTCD and to increase their growth."

05/01/2022 - "Routine use of lactulose to treat mild to moderate hyperammonemia in this patient population was not associated with improved outcomes."
12/01/1997 - "Seventy-five cirrhotic patients with hyperammonemia in the past or at the time of the study were randomly divided into two groups (treated with lactulose or nontreated) in 14 hospitals in Japan. "
04/17/2021 - "Noncirrhotic hyperammonemia is an infrequent presentation and is treated with lactulose. "
12/01/2018 - "Cross-over study in hyperammonemia patients for efficacy, safety, and acceptability of a new lactulose preparation (SK-1202) compared to approved drug."
05/01/2022 - "When analyzed separately, patients with moderate hyperammonemia (60-99 μmol/L) who received lactulose had longer hospital and ICU length of stay compared to non-lactulose (417.8 hours vs. 208.4 hours, P = 0.003, and 229.2 hours vs. 104.7 hours, P = 0.025; respectively), though confounders were present. "

11/01/2022 - "Moving towards a novel therapeutic strategy for hyperammonemia that targets glutamine metabolism."
01/01/2022 - "This review focuses on the effects of hyperammonemia on the two glutamine carriers located in the astrocytic membrane: Slc38a3 (SN1, SNAT3) and Slc7a6 (y + LAT2). "
01/01/2019 - "Her plasma glutamine concentration was near normal and she had mild hyperammonemia. "
01/01/2017 - "We propose MRS to monitor brain glutamine as a noninvasive approach to be utilized for diagnostic and therapeutic monitoring purposes in adult patients presenting with idiopathic hyperammonemia."
01/01/2017 - "We hypothesize that the slower clearance for brain glutamine levels accounts for the delay in improvement following initiation of treatment in cases of chronic hyperammonemia. "

12/01/2015 - "This study demonstrated that introduction of new AEDs changed the co-prescribing pattern in patients receiving valproic acid, resulting in a marked decrease of hyperammonemia. "
01/01/2023 - "Pending larger studies, VIE in SE seems relatively frequent and difficult to foresee; clinical alertness to symptoms is mandatory, even without hyperammonemia, and valproate withdrawal should be considered in suspected cases."
10/01/2023 - "Hyperammonemia can occur after acute overdose or chronic use of valproic acid (VPA). "
05/01/2023 - "Valproic acid-associated hyperammonemia is a common adverse effect that may occur within therapeutic range of VPA. "
05/01/2023 - "Hyperammonemia is an adverse effect that poses clinical uncertainty around valproic acid (VPA) use. "

08/01/1976 - "We conclude that this therapy provides safe and effective long-term management for this patient's disorder and may be useful in other cases of congenital hyperammonemia."
11/01/2019 - "Here, we investigated the efficacy of liver-specific GS overexpression for therapy of hyperammonemia. "
01/01/2023 - "Patients with CD develop hepatosteatosis and hyperammonemia but there is no effective therapy for CD. "
08/01/2021 - "Reduced eGFR is considered a risk factor of developing hyperammonemia during FOLFOX therapy. "
08/01/2021 - "By multivariate analysis, estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 was independently associated with hyperammonemia during FOLFOX therapy (odds ratio: 9.0, p = 0.040). "

03/01/2015 - "This study adds to the understanding of chemotherapy-induced hyperammonemia as drug-induced CPS1 deficiency is suggested. "
10/01/2020 - "It was successfully managed with a combination of interventional radiology and pharmacotherapy, to improve hepatic function, including hyperammonemia and to control portal-splenic venous hemodynamics with hepatic venous pressure gradient (HVPG) monitoring. "
01/01/2018 - "Then, we hypothesized that chemotherapy may increase the incidence of hyperammonemia without comparable change of major parameters of hepatic/renal disorder. "
01/01/2018 - "On the fifth day of first cycle chemotherapy, she developed hyperammonemia (245 µmol/L) and psychiatric symptoms. "
03/01/2015 - "We therefore hypothesized that the acute onset of hyperammonemia was due to an acquired, chemotherapy-induced (posttranscriptional) CPS1 deficiency. "

01/01/2023 - "The Case | Hyperammonemia in a non-cirrhotic hemodialysis patient."
01/01/2022 - "Hemodialysis, having more than 1 indication for RRT in addition to hyperammonemia, and complications during RRT were all risk factors for mortality. "
03/26/2021 - "This broadens the so far known differential diagnosis of severe neonatal hyperammonemia requiring hemodialysis."
10/01/2020 - "Our case suggests that early hemodialysis and pharmacologic interventions for acute neonatal hyperammonemia can improve the prognosis of patients with neonatal-onset CPS1D."
02/01/2018 - "To describe our experience with continuous extracorporeal dialysis in severely ill neonates with hyperammonemia. "

10/01/2016 - "Cox proportional hazards regression model clearly showed reducing hyperammonemia by 48 hours after initiating continuous renal replacement therapy significantly improved survival (HR, 1.04; 95% CI, 1.013-1.073; p = 0.004). "
07/01/2020 - "CONCLUSION: MS represent an effective treatment for hyperammonemia and should be available in all pediatric units to avoid the need for CVVHD. "
05/01/2023 - "Continuous renal replacement therapy (CRRT) in neonates and children has recently been used to treat hyperammonemia and metabolic disorders. "
01/01/2023 - "Continuous Renal Replacement Therapy for Hyperammonemia Beyond Infancy."
01/01/2022 - "Our large, multicenter retrospective review supports the use of continuous renal replacement therapy for neonatal hyperammonemia."

10/27/2023 - "In this study, we aimed to evaluate the effect of two subacute oral administrations of flaxseed oil (0.26 and 0.52 mL/kg) on short- and long-term memory, visuospatial memory, locomotor activity, motor coordination, and the neuronal morphology of the prefrontal cortex (PFC) via tests on Wistar rats with hyperammonemia. "
01/01/1995 - "She suffered a consciousness disturbance due to hyperammonemia, which was successfully treated by oral administration of sodium benzoate before surgery. "
10/01/1992 - "Acute, oral administration of 14.3 to 37.5 mg/kg magnesium valproate (peak serum concentrations, 65 to 139 micrograms/ml) increases spike-wave frequency at 2, 3, 4, and 5 hours postdrug, in the absence of hyperammonemia or significant correlations with ammonemia fluctuations. "
11/01/1982 - "After oral administration of D,L-carnitine (50 mg/kg/day) for four weeks, both carnitine deficiency and hyperammonemia were corrected."
01/02/1978 - "The effect of glucose oral administration on hyperammonemia in cirrhotics."