Intertrigo is a common inflammatory
dermatosis of opposing skin surfaces that can be caused by a variety of infectious agents, most notably candida, under the effect of mechanical and environmental factors. Symptoms such as
pain and
itching significantly decrease quality of life, leading to high morbidity. A multitude of predisposing factors, particularly
obesity,
diabetes mellitus, and immunosuppressive conditions facilitate both the occurrence and recurrence of the disease. The diagnosis of candidal
intertrigo is usually based on clinical appearance. However, a range of laboratory studies from simple tests to advanced methods can be carried out to confirm the diagnosis. Such tests are especially useful in treatment-resistant or recurrent cases for establishing a differential diagnosis. The first and key step of management is identification and correction of predisposing factors. Patients should be encouraged to lose weight, followed up properly after endocrinologic treatment and intestinal colonization or periorificial
infections should be medically managed, especially in recurrent and resistant cases. Medical treatment of candidal
intertrigo usually requires
topical administration of
nystatin and
azole group antifungals. In this context, it is also possible to use magistral remedies safely and effectively. In case of predisposing immunosuppressive conditions or generalized
infections, novel systemic agents with higher potency may be required.