Investigational drugs for the treatment of endometriosis, an update on recent developments.

Abstract

INTRODUCTION:

Endometriosis is a hormone-dependent benign chronic disease that requires a chronic medical therapy. Although currently available drugs are efficacious in treating endometriosis-related pain, some women experience partial or no improvement. Moreover, the recurrence of symptoms is expected after discontinuation of the therapies. Currently, new drugs are under intense clinical investigation for the treatment of endometriosis.

AREAS COVERED:

This review aims to offer the reader a complete and updated overview on new investigational drugs and early molecular targets for the treatment of endometriosis. The authors describe the pre-clinical and clinical development of these agents.

EXPERT OPINION:

Among the drugs under investigation, late clinical trials on gonadotropin-releasing hormone antagonists (GnRH-ant) showed the most promising results for the treatment of endometriosis. Aromatase inhibitors (AIs) are efficacious in treating endometriosis related pain symptoms but they cause significant adverse effects that limit their long-term use. New targets have been identified to produce drugs for the treatment of endometriosis, but the majority of these new compounds have only been investigated in laboratory studies or early clinical trials. Thus, further clinical research is required in order to elucidate their efficacy and safety in human.

• Authors: Fabio Barra, Carolina Scala, Valerio Mais, Stefano Guerriero, Simone Ferrero
• Journal: Expert opinion on investigational drugs (Expert Opin Investig Drugs) Vol. 27 Issue 5 Pg. 445-458 (05 2018) ISSN: 1744-7658 [Electronic] England
• PMID: 29708812 (Publication Type: Journal Article, Review)

Chemical References

• Aromatase Inhibitors
• Drugs, Investigational
• Hormone Antagonists
• Gonadotropin-Releasing Hormone

Topics

• Animals
• Aromatase Inhibitors (adverse effects, pharmacology, therapeutic use)
• Drug Design
• Drugs, Investigational (adverse effects, pharmacology, therapeutic use)
• Endometriosis (drug therapy, physiopathology)
• Female
• Gonadotropin-Releasing Hormone (antagonists & inhibitors)
• Hormone Antagonists (adverse effects, pharmacology, therapeutic use)
• Humans
• Molecular Targeted Therapy
• Pain (drug therapy, etiology)