Abstract | BACKGROUND: Perfluoroalkyl substances (PFASs) are persistent chemicals with suspected endocrine disrupting abilities applied in consumer products. PFASs have potentially modulating effects on glucose homeostasis. Insulin resistance prevails during third trimester of pregnancy, and this challenge of glucose homeostasis may reveal putative effects of PFAS concentrations on glycemic status. OBJECTIVE: METHODS: RESULTS: In women with high risk for GDM, a two-fold increase in PFHxS concentration was significantly associated with increased fasting glucose, fasting insulin and HOMA-IR after adjusting for age, parity, educational level and pre-pregnancy BMI. Adjusting for the same confounders, a doubling in PFNA concentration was associated with higher fasting insulin and HOMA-%β. In women with low GDM risk, no associations were found between PFAS concentrations and glucose-related outcomes. CONCLUSION: PFHxS and PFNA concentrations were associated with impaired glycemic status in metabolically vulnerable pregnant women and might further enhance the risk of developing GDM.
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Authors | Richard Christian Jensen, Dorte Glintborg, Clara Amalie Gade Timmermann, Flemming Nielsen, Henriette Boye Kyhl, Helle Raun Andersen, Philippe Grandjean, Tina Kold Jensen, Marianne Andersen |
Journal | Environment international
(Environ Int)
Vol. 116
Pg. 101-107
(07 2018)
ISSN: 1873-6750 [Electronic] Netherlands |
PMID | 29660612
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2018 Elsevier Ltd. All rights reserved. |
Chemical References |
- Blood Glucose
- Fluorocarbons
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Topics |
- Blood Glucose
(analysis)
- Cohort Studies
- Denmark
(epidemiology)
- Female
- Fluorocarbons
(blood)
- Humans
- Pregnancy
(blood, statistics & numerical data)
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