Desipramine-, not tartrazine-, induced drug eruption.

Abstract	A 46-year-old woman's antidepressant therapy was changed from doxepin to desipramine because of sedative side effects. Within ten days of initiation of desipramine, a pruritic, morbilliform rash developed. The rash extended despite attempts to continue therapy with a tartrazine-free desipramine as well as antihistamines and prednisone. The rash promptly improved when desipramine was discontinued. Classic drug eruptions are quite uncommon with tricyclic antidepressants. Tartrazine, a common additive in the food and drug industry, is implicated in a number of hypersensitivity reactions. Our report presents an apparent case of desipramine-induced drug rash independent of tartrazine, and discusses the nonassociation of tartrazine.
Authors	A Ellsworth, D Gross
Journal	Drug intelligence & clinical pharmacy (Drug Intell Clin Pharm) Vol. 21 Issue 6 Pg. 510-2 (Jun 1987) ISSN: 0012-6578 [Print] United States
PMID	2956078 (Publication Type: Case Reports, Journal Article)
Chemical References	Azo Compounds Tartrazine Desipramine
Topics	Azo Compounds (adverse effects) Desipramine (adverse effects) Drug Eruptions (etiology) Female Humans Middle Aged Tartrazine (adverse effects)

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