Condyloma acuminatum (CA), or
genital wart, is a
sexually transmitted infection caused by human papillomaviruses. Increasing evidences demonstrated that
photodynamic therapy (
PDT) is effective in eliminating latent
HPV infection, the major reason for CA recurrence. We observed an increasing number of
infections after
PDT in CA patients, which has not been reported before. This study aims to evaluate the incidence and management of
infection in CA patients after
PDT procedure. CA patients received
PDT from January 2015 to February 2016 at the outpatient setting. Patients were randomly divided into two groups: the control group and
fusidic acid group. Patients in the
fusidic acid group used topical
fusidic acid (2%) and recombinant human
interferon after 5-aminolevulinic
acid (ALA)-
PDT procedure, while patients in the control group only used recombinant human
interferon. Patients came to our department for follow-up evaluations at 4, 8, and 12 weeks
after treatment for three times of
PDT. Patients with ALA-
PDT-associated
infection were then randomly divided into two groups: the
fusidic acid group and
mupirocin group. During the 13-month study period, a total of 718 patients with 2154 times of
PDT procedures were enrolled. The
infection rate after
PDT was 8.5% in the control group, while it was 1.1% in the prophylactic topical
fusidic acid group. The cure rate of
PDT-associated
infection was 85.7% in the
fusidic acid group and 86.7% in the
mupirocin group. In conclusion, prophylactic topical
antibiotic was useful for reduction of
PDT-associated
infection and optimal wound healing in CA patients.