The Relationship between Trypsin/Calcitonin Gene Related Peptide (CGRP) in Serum and Acute Pancreatitis (AP).

Abstract

BACKGROUND:

Activation of trypsin from proteolytic cleavage of trypsinogen in the pancreas can lead to acute pancreatitis. Calcitonin gene related peptide (CGRP) from both peripheral and central neurons is involved in a variety of physiological/pathophysiological processes, especially sensory (nociceptive) and efferent (effector) functions. To better understand the change of trypsin/CGRP in acute pancreatitis, the study investigated the serum level of trypsin/CGRP in patients with acute pancreatitis.

METHODS:

The study investigated 140 patients with acute pancreatitis, including 72 cases of biliary acute pancreatitis, 60 cases of hyperlipidemic acute pancreatitis, and 8 cases of idiopathic acute pancreatitis. Sixty volunteers acted as the normal control group. The levels of trypsin and CGRP in serum were analyzed.

RESULTS:

The serum levels of trypsin and CGRP in males with acute pancreatitis were higher than in females, but there was no statistical difference (p > 0.05). However, the serum levels of trypsin and CGRP in different types of acute pancreatitis were significantly higher than controls (p < 0.001), and the level of trypsin and CGRP in serum of patients with inflammation effusion was significantly higher than patients without inflammation effusion (p < 0.001). In addition, the serum levels of trypsin and CGRP in patients with I-II, III, IVA and IVB acute pancreatitis were higher than controls (p < 0.001).

CONCLUSIONS:

According to the results, we concluded that the trypsin and CGRP in serum can act as a new detection index of acute pancreatitis occurring. The serum levels of trypsin and CGRP in patients with acute pancreatitis is able to determine whether inflammation effusion happens.

• Authors: Jianxiong Hu, Wei Lin, Chengfei Zhao, Jianfang Chen
• Journal: Clinical laboratory (Clin Lab) Vol. 64 Issue 1 Pg. 93-97 (Jan 01 2018) ISSN: 1433-6510 [Print] Germany
• PMID: 29479871 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Trypsin
• Calcitonin Gene-Related Peptide

Topics

• Acute Disease
• Adult
• Biomarkers (blood)
• Calcitonin Gene-Related Peptide (blood)
• Female
• Humans
• Inflammation (blood, diagnosis)
• Male
• Pancreatitis (blood, diagnosis)
• Pleural Effusion (blood, diagnosis)
• Trypsin (blood)