Trypsin

A serine endopeptidase that is formed from TRYPSINOGEN in the pancreas. It is converted into its active form by ENTEROPEPTIDASE in the small intestine. It catalyzes hydrolysis of the carboxyl group of either arginine or lysine. EC 3.4.21.4.

Also Known As:

Networked: 3665 relevant articles (87 outcomes, 308 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Stenman, Ulf-Håkan: 17 articles (01/2012 - 02/2002)
2.	Sahin-Tóth, Miklós: 14 articles (10/2013 - 06/2002)
3.	Lerch, Markus M: 12 articles (07/2015 - 02/2002)
4.	Kido, Hiroshi: 12 articles (09/2014 - 05/2002)
5.	Witt, Heiko: 11 articles (10/2013 - 10/2002)
6.	Férec, Claude: 11 articles (10/2013 - 02/2002)
7.	Hirota, Masahiko: 10 articles (01/2012 - 01/2002)
8.	Mayerle, Julia: 9 articles (07/2015 - 02/2002)
9.	Chen, Jian-Min: 9 articles (10/2013 - 02/2002)
10.	Whitcomb, David C: 9 articles (09/2012 - 09/2002)

Related Diseases

1.	Pancreatitis 03/01/2005 - "Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice." 07/01/2015 - "Continued experimental studies are necessary to determine the specific relationships between trypsin-antitrypsin imbalance and genetic heterogeneity in pancreatitis. " 08/01/2008 - "The aim of this study was to investigate the prevalence of genetic variants of the trypsin inhibitor, SPINK1, in acute pancreatitis. " 03/01/2007 - "In this study, elimination of trypsin-like enzyme activity (TLE) and cationic trypsin-like immunoreactivity (TLI) using low-volume CHDF was examined at the first CHDF session in eight patients with severe acute pancreatitis. " 06/01/2006 - "Recent studies, using mice in which the trypsin inhibitor gene has been deleted or overexpressed, provide novel insights into the role of SPINK in pancreatic development and pancreatitis."
2.	Infection 02/01/1988 - "The screened group, detected with an improved neonatal screening assay for immunoreactive trypsin, developed fewer chest infections requiring treatment and gained more weight than the unscreened group. " 02/01/2001 - "In the present studies the protective efficacy of soyabean trypsin inhibitor (TI) was investigated on the gut following rotavirus (RV) infection in inbred mice. " 03/01/1991 - "The efficacy of trypsin treatment has been thus established and the necessity of active detection and treatment of chronic carriers of herpetic infection by the proposed method is advocated." 07/01/2003 - "Ultimately, the variable response of cell lines to ODV of different viruses, and the variable effects of trypsin on the ODV may lead to an improved understanding of the infection process of this virus phenotype as well as factors relating to baculovirus host range." 01/01/1981 - "In such assays the factor was found to be inactivated by trypsin and pH 2 and 56 degrees C for 1 hr. The serum factor did not confer protection against EMC virus infection of L-929, BHK, Hak or primary hamster embryo cells. "
3.	Chronic Pancreatitis 01/01/1985 - "In chronic pancreatitis, in a stage of remission, the level of serum immunoreactive trypsin is significantly lower as compared with the control group (p less than 0,01). " 03/01/2012 - "Pancreatic secretory trypsin inhibitor I reduces the severity of chronic pancreatitis in mice overexpressing interleukin-1β in the pancreas." 07/01/2007 - "The diagnostic power of endoscopy may be enhanced by the collection of a pancreatic juice sample after enteral feed stimulation because measurement of the trypsin content will identify chronic pancreatitis patients who will be benefited by enzyme supplementation." 01/01/1985 - "The serum immunoreactive trypsin (determined by RIA-gnost Trypsin of the firm Höchst) was studied in 30 patients with chronic pancreatitis: 16 patients in a stage of exacerbation and 14 patients with clinical remission. " 01/01/2005 - "In this study, we tested the hypothesis that the E32del genetic variant of mesotrypsin might represent a risk factor for the development of chronic pancreatitis, as a result of enhanced degradation of pancreatic secretory trypsin inhibitor. "
4.	Neoplasms (Cancer) 01/01/2014 - "This study provides evidence that Tris-Trypsin-Triton treated acellular tumor extracellular matrices are promising 3D scaffolds with ideal spatial arrangement, biomechanical properties and biocompatibility for improved modeling of 3D tumor microenvironments. " 02/01/2014 - "In the present study, a fusion protein containing the GRP78 binding peptide WIFPWIQL and the active fragment of mung bean trypsin inhibitor was constructed, and its targeted anti-tumor effects were investigated both in vitro and in vivo. " 01/01/2012 - "The results showed that trypsin, a commonly used reagent in CSCs studies, most aggressively reduced antigenicity for surface markers and make part of CD44(+)CD24(-) CSCs subpopulation cleaved into CD44(+)CD24(-) non-stem cancer cells (NSCCs). " 12/01/2011 - "The present study was performed to identify the trypsin-like protease which had previously been found to activate progalanin in this tumor tissue. " 04/01/2010 - "The purpose of this study was to investigate the secretion of tumor-derived trypsin and the expression of its specific receptor, protease-activated receptor-2 (PAR-2), in ICC using cell lines and surgical specimens. "
5.	Wounds and Injuries (Trauma) 05/20/2015 - "After immobilization, trypsin retained its collagenolytic activity, indicating this material as a promising material for wound dressing applications. " 08/13/2014 - "Using a standard benchtop spectrometer to monitor the increase in fluorescence intensity, trypsin was detected at a concentration of 250 μg/mL, i.e., in a concentration that is typical for abnormal proteolytic activity in wound fluids. " 01/01/2013 - "We find that 20 to 200 ng/ml trypsin (concentrations similar to those used in wound dressings) potentiates the differentiation of human monocytes to fibrocytes in cell culture. " 08/01/2011 - "Regulation of trypsin activity by peptide fraction of an aqueous extract of human placenta used as wound healer." 06/01/2001 - "Wound-induced accumulation of trypsin inhibitor protein was also observed by western blot analysis. "

Related Drugs and Biologics

1.	Chymotrypsin
2.	Amylases
3.	Peptide Hydrolases (Proteases)
4.	Thrombin
5.	Bromelains (Bromelain)
6.	urinastatin (MR 20)
7.	Proteins (Proteins, Gene)
8.	Protease Inhibitors (Protease Inhibitor)
9.	Lipase (Acid Lipase)
10.	Pancreatic Elastase (Elastase)

Related Therapies and Procedures

1.	Oral Administration
2.	Ligation
3.	Radiotherapy
4.	Aftercare (After-Treatment)
5.	Gastrectomy