Abstract |
Reliable markers for the rapid discrimination of severe renal damage remain a vital concern for lupus nephritis (LN). To determine a better tool for kidney damage detection, the present study compared the evaluation ability of novel urinary cytokines and chemokines (namely urinary monocyte chemoattractant protein 1 (uMCP-1), tumor necrosis factor-like weak inducer of apoptosis (uTWEAK)) with traditional serum or urinary markers (namely urinary alpha 1-microgrobulin (uα1-MG), beta 2-microglobulin (uβ2-MG) and serum complement C3 ( C3), complement C4 (C4), creatinine (Cr), blood urea nitrogen (BUN) and cystatin C (Cys C)) in discriminating LN renal damage. Correlations between markers with Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) renal SLEDAI scores, biopsy activity index (BAI) and biopsy chronicity index ( BCI) scores were evaluated. Receiver operating characteristic (ROC) curves were generated to evaluate a single or combined model in discriminating active renal involvement (rSLEDAI scores > 0) and patients with poor pathological outcome (BAI scores ≥ 7). uMCP-1 and uTWEAK possess higher correlation coefficients with renal damage and larger areas under ROC curves (AUCs) than other markers. A combined model of uMCP-1 and uTWEAK showed an AUC of 0.887, sensitivity of 86.67% and specificity of 80.00% to discriminate active LN, and an AUC of 0.778, sensitivity of 75.00% and specificity of 81.82% to discriminate LN with poor outcome, which are better than the utility of any markers individually.
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Authors | X W Dong, Z H Zheng, J Ding, X Luo, Z Q Li, Y Li, M Y Rong, Y L Fu, J H Shi, L C Yu, Z B Wu, P Zhu |
Journal | Lupus
(Lupus)
Vol. 27
Issue 6
Pg. 971-981
(May 2018)
ISSN: 1477-0962 [Electronic] England |
PMID | 29451067
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Biomarkers
- CCL2 protein, human
- Chemokine CCL2
- Cytokine TWEAK
- TNFSF12 protein, human
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Topics |
- Adolescent
- Adult
- Aged
- Area Under Curve
- Biomarkers
(blood, urine)
- Biopsy
- Case-Control Studies
- Chemokine CCL2
(urine)
- Cytokine TWEAK
(urine)
- Female
- Humans
- Lupus Nephritis
(blood, diagnosis, urine)
- Male
- Middle Aged
- Predictive Value of Tests
- ROC Curve
- Reproducibility of Results
- Severity of Illness Index
- Urinalysis
(methods)
- Young Adult
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