Complement C3 (C3 Complement)

A glycoprotein that is central in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C3 can be cleaved into COMPLEMENT C3A and COMPLEMENT C3B, spontaneously at low level or by C3 CONVERTASE at high level. The smaller fragment C3a is an ANAPHYLATOXIN and mediator of local inflammatory process. The larger fragment C3b binds with C3 convertase to form C5 convertase.

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Networked: 812 relevant articles (13 outcomes, 85 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Cianflone, Katherine: 9 articles (01/2014 - 10/2003)
2.	Carter, Angela M: 6 articles (09/2012 - 11/2005)
3.	Liu, Yang: 5 articles (11/2015 - 05/2014)
4.	Karsdal, Morten A: 5 articles (02/2015 - 01/2013)
5.	Onat, Altan: 5 articles (12/2012 - 07/2004)
6.	Can, Günay: 5 articles (12/2012 - 07/2004)
7.	Grant, Peter J: 5 articles (04/2009 - 11/2005)
8.	Jiang, Jun: 4 articles (11/2015 - 08/2015)
9.	Tang, Wu-Neng: 4 articles (11/2015 - 08/2015)
10.	Kuang, Sheng-Yao: 4 articles (11/2015 - 08/2015)

Related Diseases

1.	Infection 01/01/1982 - "In this study, the systemic inflammatory response of mice to infection with Trypanosoma cruzi was characterized with respect to induction of SAP as well as to stage-specific alterations on complement C3 and C4 levels. " 01/01/2014 - "Autologous transfusion is already a widely accepted transfusion method at present, and it can increase TNF-α and complement C3 levels in the body of surgically treated patients to strengthen immune ability against infection." 01/01/2013 - "Immunological and molecular evaluation of a patient presenting with recurrent infections caused by Streptococcus pneumoniae and low complement component 3 (C3) levels. " 09/01/2012 - "Altered levels of serum complement C3 and IL-1β might be responsible for depressed immune response which might be causes for delayed wound healing and repeated infections. " 01/01/2012 - "Three days after oral infection of adult zebrafish with Aeromonas hydrophila harboring pRAS1, elevated expression of pro-inflammatory cytokine (TNF α, IL-1β and IL-8) and complement C3 genes in the intestine coincided with disease symptoms. "
2.	Inflammation 11/01/2004 - "In this study, we quantitatively identified the fragment f of complement 3 (C3f), which is important in inflammation. " 05/01/2013 - "The finding of inflammation mediated factor Complement C3 revealed that inflammation might be closely related with the occurrence and development process of PDAC." 09/01/2011 - "Keratinocytes synthesize complement component 3 (C3) constitutively, and increased expression of C3 has been described during skin inflammation. " 09/01/2011 - "A protective role of complement component 3 in T cell-mediated skin inflammation." 01/01/2011 - "Isolated glomerular accumulation of complement component 3 (C3) is typical with variable degrees of glomerular inflammation. "
3.	Macular Degeneration (Age-Related Maculopathy) 01/01/2011 - "A common complement C3 variant is associated with protection against wet age-related macular degeneration in a Japanese population." 05/01/2015 - "Nonsynonymous single nucleotide polymorphisms (SNPs) in complement component 3 (CC3) are associated with the risk of age-related macular degeneration (AMD), however, this association is not consistent among studies. " 01/01/2015 - "The association between the rs2230199 C>G single nucleotide polymorphism (SNP) in complement component 3 and age-related macular degeneration (AMD) risk has been examined extensively but the results are not consistent among studies. " 05/01/2015 - "Nonsynonymous single nucleotide polymorphisms in the complement component 3 gene are associated with risk of age-related macular degeneration: a meta-analysis." 11/01/2013 - "Identification of a rare coding variant in complement 3 associated with age-related macular degeneration."
4.	Nephrotic Syndrome (Syndrome, Nephrotic) 10/01/2011 - "To study serum acylation-stimulating protein (ASP) and complement 3 (C3) levels and their relationship with blood lipids in children with primary nephrotic syndrome (PNS). " 05/01/1982 - "The clinical picture associated with this pattern varies between apparent acute glomerulonephritis (GN), the steroid-resistent nephrotic syndrome, a combination of both, or asymptomatic protein uria and microscopic hematuria--with or without persistent depression of serum complement (C3). " 04/01/2013 - "Low serum level of IgG, complement C3 and C4 in nephrotic syndrome children may cause increased susceptibility to infection. " 06/01/2008 - "In this study, we evaluated acylation-stimulating protein (ASP) and complement component 3 (C3) in children (n=48) with various forms of proteinuric renal disease [nephrotic syndrome, acute poststreptococcal infection glomerulonephritis (APSGN), and lupus nephritis (LN)] in comparison with age- and gender-matched controls (n=279). " 01/01/1988 - "Continued treatment with chlorambucil + low-dose prednisolone led to a complete and stable remission of the nephrotic syndrome, and the C3 complement normalized. "
5.	Nephritis 08/01/2010 - "As expected, the patients with membranous nephritis had lower anti-dsDNA titres and higher complement C3 levels at baseline, but in both groups a significant reduction in anti-dsDNA titre and improvements in complement C3 levels were seen during the first 6 months after treatment; the kinetics of improvement were similar in both groups. " 01/01/2011 - "According to clinical manifestations, patients with arthritis showed higher levels of ESR (34 vs. 20 mm/h), CRP (10 vs. 2.8 mg/L), and AAT (179 vs. 145 mg/dL), but lower Tf (192 vs. 226 mg/dL) than those without arthritis; whereas active nephritis was characterized by lower serum concentrations of complement C3 (73 vs. 92 mg/dL), C4 (10 vs. 15 mg/dL), CH50% (80 vs. 160 U/mL) and Tf (196 vs. 232 mg/dL) than those patients without this manifestation. " 11/20/1993 - "Human renal epithelial and mesangial cells have been shown to synthesise complement C3 in culture, but the relevance of this finding to the development of complement-mediated nephritis is uncertain. " 11/20/1993 - "Endogenous complement C3 synthesis in immune complex nephritis." 07/01/1991 - "As compared with a group of lupus patients without nephritis, patients with nephritis had lower serum complement C3 (p less than 0.05) and C4 (p less than 0.005) levels and higher serum DNA binding activity (p less than 0.001). "

Related Drugs and Biologics

1.	Immunoglobulin G (IgG)
2.	Complement System Proteins (Complement)
3.	Immunoglobulins (Immunoglobulin)
4.	C-Reactive Protein
5.	Immunoglobulin A (IgA)
6.	Acute-Phase Proteins (Acute-Phase Protein)
7.	Antigen-Antibody Complex (Immune Complex)
8.	Hormones
9.	Interleukin-6 (Interleukin 6)
10.	cobra venom factor

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Transplantation (Transplant Recipients)
3.	Continuous Ambulatory Peritoneal Dialysis (CAPD)
4.	Ligation
5.	Drug Therapy (Chemotherapy)