Association Between Clinicopathological Features and Programmed Death Ligand 1 Expression in Non-small Cell Lung Cancer.

Abstract

BACKGROUND/AIM:

Programmed cell death ligand 1 (PD-L1) expression is a predictive marker for immunotherapy effects in advanced non-small cell lung cancer (NSCLC), but its association with patient characteristics or specimens is controversial. We aimed to retrospectively analyze the association of PD-L1 expression with clinicopathological features of NSCLC patients.

MATERIALS AND METHODS:

The PD-L1 expression and clinicopathological features of NSCLC patients were assessed from January 2017 to June 2017 in the Tokyo Metropolitan Cancer and Infectious Diseases Centre, Komagome Hospital were reviewed (n=108).

RESULTS:

For PD-L1 expressions of 0% and >1%, multivariate analysis showed that lymph node sample results were associated with positive PD-L1 expression. Archival samples and high serum carcinoembryonic antigen (CEA) levels were associated with negative PD-L1 expression. Sample preservation time and CEA levels correlated with PD-L1 expression.

CONCLUSION:

Nodal metastasis, sample preservation time and CEA levels were associated with PD-L1 expression in NSCLC.

• Authors: Yasuhiro Kato, Jumpei Kashima, Kageaki Watanabe, Makiko Yomota, Yositaka Zenke, Yusuke Okuma, Yukio Hosomi, Akihiko Gemma, Masahiro Seike, Tatsuru Okamura
• Journal: Anticancer research (Anticancer Res) Vol. 38 Issue 2 Pg. 1077-1083 (02 2018) ISSN: 1791-7530 [Electronic] Greece
• PMID: 29374744 (Publication Type: Journal Article)
• Copyright: Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Chemical References

• B7-H1 Antigen
• Biomarkers, Tumor
• CD274 protein, human

Topics

• Adenocarcinoma (metabolism, secondary)
• Aged
• B7-H1 Antigen (metabolism)
• Biomarkers, Tumor (metabolism)
• Carcinoma, Non-Small-Cell Lung (metabolism, secondary)
• Case-Control Studies
• Female
• Follow-Up Studies
• Humans
• Lung Neoplasms (metabolism, pathology)
• Lymphatic Metastasis
• Male
• Prognosis
• Retrospective Studies
• Survival Rate
• Tokyo