Mini-review: Can non-human leucocyte antigen genes determine susceptibility to severe dengue syndromes?

Abstract

Dengue viral infections are endemic or epidemic in virtually all tropical countries. Among individuals infected with the dengue virus, severe dengue syndromes (i.e., dengue haemorrhagic fever and dengue shock syndromes) tend to affect only some and this may be due to a combination of host genetic susceptibility and viral factors. In this review article we analyse and discuss the present knowledge of non-human leucocyte antigen host genetic susceptibility to severe dengue syndromes. The relevance of genetic polymorphisms in the pathways of antigen recognition, uptake, processing and presentation, activation of interferon α responses, mast cell and complement activation and T cell activation and dengue disease severity has been reviewed and analysed.

• Authors: Dorothy Ng, Aparna Ghosh, Mark Jit, Suranjith L Seneviratne
• Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene (Trans R Soc Trop Med Hyg) Vol. 111 Issue 9 Pg. 384-392 (09 01 2017) ISSN: 1878-3503 [Electronic] England
• PMID: 29351663 (Publication Type: Journal Article, Review)
• Copyright: © The Author(s) 2018. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail: [email protected].

Chemical References

• Antigens

Topics

• Antigens (genetics)
• Genetic Predisposition to Disease
• Humans
• Immunity (genetics)
• Polymorphism, Genetic
• Severe Dengue (genetics, immunology)
• T-Lymphocytes (immunology)