Genetic Predisposition to Disease (Genetic Predisposition)

08/01/2011 - "Further study to investigate the relationship between individual characteristics and genetic susceptibility to VCM-caused chromosome damage is warranted, it is helpful for us to understand the mechanism of VCM metabolism, to find the biomarkers of susceptibility and to recognize the susceptible individuals in the primary prevention of VCM-caused damage."
03/01/2010 - "Its detection and perhaps its disparities could be improved through the identification of genetic susceptibility biomarkers within essential biological pathways. "
12/01/1995 - "Recent advances in genetic predisposition, biomarkers, photodiagnostic imaging, and differentiation therapy may soon offer improved outcomes. "
01/01/2015 - "The review specifically covers developments in genetic predisposition, next-generation sequencing studies, biomarkers for stratification, prognosis and treatment, and other 'omics technologies such as metabolomics and proteomics. "
10/01/2014 - "No studies have evaluated genetic susceptibility and intermediate phenotypic biomarkers in Hispanics. "

04/01/1999 - "Our data suggest that insulin secretion, when expressed as an index normalized for insulin sensitivity, is more familial than either insulin sensitivity or first phase insulin secretion alone and may be a very useful trait for identifying genetic predisposition to type 2 diabetes."
10/01/2011 - "Knowledge of the genetic susceptibility, increasing ability to predict who may be at risk, recognition of the potential clinical impact of residual insulin secretion after diagnosis, and development of new immunomodulatory agents have supported an increasing number of clinical trials to prevent b-cell loss. "
12/01/2009 - "Knowledge of the genetic susceptibility, increasing ability to predict who may be at risk, recognition of the potential clinical impact of residual insulin secretion after diagnosis, and development of new immunomodulatory agents have supported an increasing number of clinical trials to prevent beta-cell loss. "
12/08/1989 - "Recent studies indicate that the subset of insulin-dependent diabetic patients who develop nephropathy may have a genetic susceptibility to renal injury resulting from the abnormal physiologic milieu associated with diabetes. "
03/31/2015 - "Insulin controls transcription to sustain its physiologic effects for the organism to adapt to environmental changes added to genetic predisposition. "

08/01/2014 - "Improved knowledge of environmental risk factors, genetic predisposition and causal genetic syndromes may improve prediction and parental counseling, and prevent co-morbidity. "
01/01/2014 - "Data from epidemiological and genetic studies further support the concept that IMIDs are interrelated, as they can co-occur in the same patient and share a similar genetic susceptibility. "
01/01/2013 - "This study confirms that H63D is a discrete genetic susceptibility factor whose expression is most visible in association with other co-factors. "
12/01/1999 - "This study used a family study method and examined the transmission of PNE in relatives of PNE and control probands with and without ADHD, to determine if these disorders co-occur due to common genetic susceptibilities or other, i.e. "
09/01/2015 - "The risk for each complication is dictated by patient characteristics including age, co-morbidities, and genetic predispositions, as well as the specifics of therapy. "

01/01/2009 - "Thrombocytes increased rapidly and transaminase improved at day 7. We report a rare case of PBC-AIH overlap syndrome with concurrent ITP and SSc which suggest the presence of shared genetic susceptibility factors in multiple autoimmune conditions including PBC, AIH, ITP and SSc."
06/01/2009 - "The purpose of this study was to investigate whether the -1516G>T, -574T>G, 4259G>T single-nucleotide polymorphisms within the TIM-3 gene contribute to the genetic susceptibility to ITP. "
01/01/2012 - "There is also evidence for a genetic predisposition to both ITP and responsiveness to therapy, which may in part lie within immune-related genes. "
10/15/2006 - "A surprisingly high number of ITP patients with a positive family history were identified, indicating the likely existence of a genetic susceptibility for ITP."
10/15/2006 - "Familial cases would make a genetic susceptibility for ITP possible. "

01/01/1996 - "Analysis of relations between the above antigens, the disease risk, clinical and laboratory parameters, readings of ultrasound histogram and the efficacy of treatment helped discover not only provoking and protecting genes, but also some pathogenetic mechanisms involved in genetic predisposition. "
09/01/2015 - "Further confirmation of a genetic predisposition comes from studies of the association between the human leukocyte antigen (HLA) system and CD. "
11/01/2011 - "The aim of this study was to test the hypothesis that closely related human leukocyte antigen (HLA) haplotypes containing the DRB1*07:01 gene ['DR7' (DRB1*07:01-DQA1*02:01-DQB1*02:01g or DRB1*07:01-DQA1*03:01-DQB1*02:01g) haplotypes] derived from European and African populations differ in their genetic susceptibility for type 1 diabetes (T1D) depending on the DQ-α molecule present. "
01/01/2011 - "Several studies from ethnically different countries have clarified that the genetic predisposition to type 1 AIH is linked mainly to human leukocyte antigen (HLA)-class II genes. "
06/01/2010 - "This potentially lethal disorder is hypothesized to have an autoimmune etiology, thus the aim of this study was to determine whether genetic susceptibility to hypoadrenocorticism in NSDTRs is associated with genes of the canine major histocompatibility complex [MHC; dog leukocyte antigen system (DLA)]. "

01/01/2012 - "The HLA-DRB1 gene locus plays a major role in genetic susceptibility to RA, a condition that has been associated with a high cardiovascular morbidity and mortality in many studies. "
02/01/2011 - "The objectives of this study are to investigate the influence of the HLA-DRB1 alleles on the genetic susceptibility to MS and to study their impact on disability progression in a Spanish population. "
05/01/2009 - "Among the RA-susceptibility genes identified by genetic studies, HLA-DRB1 gene appears to represent the most major determinant of genetic predisposition to RA. "
11/01/2004 - "This study further defines genetic susceptibility to JIA in the region centromeric to HLA-DRB1. "
05/01/2013 - "HLA-DRB1*15-DQB1*06 haplotype showed the highest risk factor for the disease that is similar to what was seen in the African American patients, suggesting shared susceptibility genetic factors among these ethnic groups."

01/01/2014 - "Our study indicates that SNP (rs2297508) of SREBF-1 may serve as a genetic predisposition factor for the development of EC and screening of such genetic marker may be helpful in its early detection."
05/01/2012 - "The analysis of heterozygosity for particular loci as genetic markers using our new study design may be an efficient and reliable approach to estimate genetic predispositions."
02/02/2011 - "A genetic predisposition for the development of symptomatic lumbar disc disease has been suggested by several twin sibling studies and subsequent genetic marker studies. "
09/01/1981 - "These findings require confirmation, but they do suggest that genetic susceptibility may be important in the development of DHF/DSS and indicate that further broader studies of genetic markers might be rewarding."
04/01/2013 - "Haplotype analysis was conducted, and an arbitrary score of genetic 'susceptibility' (S ) score ranging from -3 to +3 was assigned to donors based on the presence or absence of genetic markers. "

12/01/2013 - "Thirty-nine patients carrying the IL4 haplotype of genetic susceptibility to CP (IL4+) or protection against CP (IL4-) were evaluated. "
12/01/2013 - "The TCI/CCI IL4 haplotype, previously associated with genetic susceptibility to CP, was also associated with increased levels of periodontopathogenic bacteria, but this genetic background did not influence the response to non-surgical periodontal treatment."
06/01/2007 - "We investigated genetic predisposition in the interleukin-4 response to coronary revascularization and studied the association between C-590T polymorphism, interleukin-4 levels, and outcome of surgery. "
01/01/2015 - "The present study suggests that the IL-4 rs2243250 polymorphism might be associated with genetic susceptibility to autoimmune diseases, including RA and MS."
05/01/2002 - "To our knowledge, this study is the first to demonstrate the possibility that the IL-4 promoter gene -589 T gene polymorphism with increased IL-4 synthesis in combination with IRF-1 allele 1 confers host genetic susceptibility to SSPE in Japanese subjects."

01/20/2011 - "The present study addresses two main questions: (1) genetic susceptibility, as examined by effects of Mthfr deficiency on behavior (Experiment 1) and (2) possible gene-drug interactions as expressed by behavioral phenotyping of Mthfr-deficient mice neonatally exposed to the GABA potentiating drug GVG (Experiment 2). "
04/01/1996 - "The pivotal function of ionotropic gamma-aminobutyric acid type A receptors (GABRs) in inhibitory neurotransmission in the mammalian central nervous system suggests that they may be involved in epileptogenesis and genetic predisposition to IGEs. "
03/01/1986 - "These data and previous studies support a role for increased excitant amino acid action and decreased efficacy of GABA in the inferior colliculus as important mechanisms involved in genetic susceptibility to audiogenic seizures."
02/20/2003 - "In the present study the molecular composition of other GABA(A) subunits (beta2, alpha1 and gamma2) were analyzed in order to further investigate the involvement of the GABA(A) receptors in the genetic predisposition to voluntary alcohol intake. "
03/05/2001 - "Our data show for the first time that a mutated GABA(A) alpha(6) receptor subunit segregates in a rat line which voluntarily avoids alcohol consumption, and further support a possible involvement of the GABA(A) receptor containing a mutated alpha(6) subunit in the genetic predisposition to alcohol preference."

09/01/2014 - "Genetic predisposition to increased blood cholesterol and triglyceride lipid levels is not associated with elevated LOAD risk. "
01/01/2013 - "Nevertheless variation in baseline cholesterol levels, genetic predisposition of the subjects and compliance may contribute to a large individual variability."
01/01/2012 - "The second sample (no genetic predisposition; n = 49) was recruited among patients with CVD-risk profiles based on family history of CVD, cholesterol levels, and blood pressure, registered at general practices. "
08/01/2007 - "Plasma cholesterol homeostasis is regulated by genetic predispositions and environmental factors. "
01/01/2006 - "The CYP7A1 A-204C variant accounts for a significant proportion of the genetic predisposition of the response of plasma cholesterol levels."

11/01/1995 - "Exposure-specific strategies are described; these are such things as health promotion and behavior modification, legislative approaches, treatment for addiction, changes in the food supply, chemoprevention, occupational and environmental regulation, immunization, identification of persons with enhanced genetic susceptibility, and improved surveillance systems. "
01/01/2010 - "Apart from the biological activity of SFN, this review also focuses on its bioavailability and tissue distribution as well as individuals' genetic predispositions as significant factors influencing the potential efficiency of chemoprevention using this compound."
10/01/2014 - "For women at high risk for ovarian, endometrial and/or colorectal malignancies due to genetic susceptibilities or a strong family history, the possibility of chemoprevention with OCPs may be an attractive option; however, the potential increase in breast cancer, although small, must be considered in clinical decision-making. "
08/01/2008 - "Surveillance, chemoprevention, and prophylactic surgery are accepted options for managing individuals who have a genetic predisposition for cancer. "
07/01/2005 - "The current article reviews recent advances in genetic susceptibility and chemoprevention of lung cancer. "

01/01/2014 - "While the possibility of genetic predisposition to HIV therapeutics has potential, most studies provide inconsistent data. "
10/01/2014 - "Our data suggested cumulative increased NPC risk associations with TERT-CLPTM1L and DSBR pathways contribute to genetic susceptibility to NPC and have potential translational relevance for patient stratification and therapeutics."
08/01/2007 - "This has important clinical implications, both from the perspective of genetic susceptibility as well as clinical therapeutics."
11/01/2001 - "The recent publication of the sequence of the human genome will accelerate the discovery of new genetic susceptibility factors for human disease, leading to the development of novel diagnostics and therapeutics. "
04/01/2011 - "This suggests that understanding host-pathogen interactions at the level of host genetic susceptibility will allow the formulation of new targeted and patient-tailored antifungal therapeutics, including improved donor screening."

11/01/2013 - "Retabolil injections reduced the severity of catalepsy response in rats with genetic predisposition. "
11/01/2013 - "We studied the possibility of using anabolic steroid retabolil injections for complex correction of behavioral and immune parameters in rats with genetic predisposition to catalepsy. "
01/01/1979 - "Rats with a genetic susceptibility to salt hypertension were given repeated neonatal injections of guanethidine. "

04/01/2011 - "This suggests that understanding host-pathogen interactions at the level of host genetic susceptibility will allow the formulation of new targeted and patient-tailored antifungal therapeutics, including improved donor screening."

01/01/2011 - "Thus, the genetic predisposition of donor should be carefully considered in transplantation."
01/01/2011 - "This finding suggests that the burden of endothelial injury in a post-transplantation setting may trigger de novo HUS in the presence of mild genetic susceptibility to HUS."
01/01/2010 - "In contrast, allogeneic hematopoietic transplantation reconstitutes all blood lineages from a tissue-matched donor who presumably does not have a genetic predisposition to IBD. "
12/01/2009 - "Moreover, their frequency distribution data are important in the implementation of donor-recipient registry programs for transplantation purposes and also in determining the genetic predisposition for many diseases. "
04/01/2004 - "In particular, age, sex, pharmacokinetic properties, pharmaceutical preparation, genetic predisposition, association with other drugs and the parodontal conditions before transplantation are considered. "