Abstract | BACKGROUND: SUBJECTS/METHODS: Nondiabetic persons (n=73), recruited from the general population, underwent clinical examinations, fasting blood drawing to measure TG and adipocytokines and oral glucose tolerance testing (OGTT) to assess basal and dynamic insulin secretion and sensitivity indices. Magnetic resonance imaging and 1H-magnetic resonance spectroscopy were used to measure body fat distribution and ectopic fat content in liver and pancreas. RESULTS: In age-, sex- and BMI-adjusted analyses, total and high-molecular-weight adiponectin were the strongest negative predictors of fasting beta-cell function (BCF; β=-0.403, p=0.0003 and β=-0.237, p=0.01, respectively) and adaptation index (AI; β=-0.210, p=0.006 and β=-0.133, p=0.02, respectively). Circulating TG, but not pancreatic fat content, related positively to BCF (β=0.375, p<0.0001) and AI (β=0.192, p=0.003). Similar results were obtained for the disposition index (DI). CONCLUSIONS:
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Authors | Bettina Nowotny, Sabine Kahl, Birgit Klüppelholz, Barbara Hoffmann, Guido Giani, Roshan Livingstone, Peter J Nowotny, Valerie Stamm, Christian Herder, Andrea Tura, Giovanni Pacini, Jong-Hee Hwang, Michael Roden |
Journal | Metabolism: clinical and experimental
(Metabolism)
Vol. 81
Pg. 113-125
(04 2018)
ISSN: 1532-8600 [Electronic] United States |
PMID | 29273469
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2017 Elsevier Inc. All rights reserved. |
Chemical References |
- ADIPOQ protein, human
- Adiponectin
- Fatty Acids, Nonesterified
- Insulin
- Lipids
- Triglycerides
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Topics |
- Adiponectin
(blood)
- Aged
- Fatty Acids, Nonesterified
(blood)
- Female
- Humans
- Insulin
(metabolism)
- Insulin Resistance
- Insulin Secretion
- Insulin-Secreting Cells
(physiology)
- Lipids
(physiology)
- Male
- Middle Aged
- Triglycerides
(blood)
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