Cancer nanotheranostics, integrating both diagnostic and therapeutic functions into nanoscale agents, are advanced solutions for
cancer management. Herein, a light-responsive biodegradable nanorattle-based
perfluoropentane-(PFP)-filled mesoporous-
silica-film-coated
gold nanorod (GNR@SiO2 -PFP) is strategically designed and prepared for enhanced ultrasound (US)/photoacoustic (PA) dual-modality imaging guided
photothermal therapy of
melanoma. The as-prepared nanorattles are composed of a thin mesoporous
silica film as the shell, which endows the nanoplatform with flexible morphology and excellent biodegradability, as well as large cavity for PFP filling. Upon 808 nm
laser irradiation, the loaded PFP will undergo a liquid-gas phase transition due to the heat generation from GNRs, thus generating nanobubbles followed by the coalescence into
microbubbles. The conversion of nanobubbles to
microbubbles can improve the intratumoral permeation and retention in nonmicrovascular tissue, as well as enhance the
tumor-targeted US imaging signals. This nanotheranostic platform exhibits excellent biocompatibility and biodegradability, distinct gas bubbling phenomenon, good US/PA imaging contrast, and remarkable photothermal efficiency. The results demonstrate that the GNR@SiO2 -PFP nanorattles hold great potential for
cancer nanotheranostics.