Microbubbles

Small encapsulated gas bubbles (diameters of micrometers) that can be used as CONTRAST MEDIA, and in other diagnostic and therapeutic applications. Upon exposure to sufficiently intense ultrasound, microbubbles will cavitate, rupture, disappear, release gas content. Such characteristics of the microbubbles can be used to enhance diagnostic tests, dissolve blood clots, and deliver drugs or genes for therapy.

Also Known As:

Networked: 1136 relevant articles (69 outcomes, 171 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Porter, Thomas R: 23 articles (09/2015 - 03/2002)
2.	Wang, Zhigang: 21 articles (01/2016 - 03/2008)
3.	Willmann, Jürgen K: 21 articles (01/2016 - 02/2008)
4.	Klibanov, Alexander L: 21 articles (11/2015 - 04/2002)
5.	Xie, Feng: 19 articles (09/2015 - 07/2003)
6.	Liu, Zheng: 18 articles (11/2015 - 12/2004)
7.	Kiessling, Fabian: 16 articles (09/2015 - 10/2003)
8.	Lindner, Jonathan R: 16 articles (04/2015 - 04/2002)
9.	Maruyama, Hitoshi: 15 articles (12/2015 - 03/2008)
10.	Yokosuka, Osamu: 15 articles (12/2015 - 03/2008)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2013 - "Complete replenishment of tumor vasculature with silencing gene-bearing microbubbles in between destructive pulses of UTMD is required to maximize the efficacy of anti-angiogenic cancer gene therapy.Molecular" 01/01/2015 - "In addition, microbubbles notably improved tumor tissue destruction caused by ultrasound and SDT treatment. " 08/10/2014 - "The results demonstrated that although the delivery is heterogeneous within tumors, there is a significant improvement in the delivery and the microscopic distribution of both nanoparticles and a released model drug when the nanoparticles are combined with microbubbles and ultrasound. " 06/01/2013 - "Microbubble-assisted/US-mediated Ad.p53 and Ad.RB treated tumors showed significant reduction in tumor volume compared to Ad.p130 treated tumors (p<0.05). " 10/01/2010 - "Then, once unbound microbubbles had cleared from the circulation, a strong enhancement of the tumor was obtained with BR55, whereas no significant microbubble accumulation was detected in the healthy prostate tissue. "
2.	Stroke (Strokes) 12/01/2010 - "The motion of microbubbles stimulated by ultrasound can be used to increase drug penetration through tissues and has been shown to be effective in breaking up clots in stroke patients (without increased risk). " 01/01/2015 - "Microcirculation, irrespective of recanalization, may also be improved by US and microbubbles, and this effect may open new opportunities for the application of sonothrombolysis in acute ischemic stroke. " 01/01/2015 - "Clinical studies support the use of US for ischemic stroke therapy, and the first trials of enhancing sonothrombolysis with microbubbles have been encouraging. " 11/01/2012 - "To study the treatment of ischemic stroke with combining targeted-microbubbles with low frequency ultrasound in animal model. " 11/01/2012 - "[Animal study in combining targeted-microbubbles with low-frequency ultrasound for the treatment of ischemic stroke]."
3.	Fibrosis (Cirrhosis) 10/01/2013 - "New dedicated software packages allow the accurate quantification of the enhancement within the small bowel wall after microbubble contrast agent injection to obtain different kinetic semi-quantitative parameters-the percentage of the maximal enhancement, the time-to-the peak enhancement, and the area under the time-intensity curve-which are very useful to differentiate the inflammatory oedema from fibrosis and to differentiate responders from non-responders to the specific therapy among patients with CD. " 01/01/2015 - "This study was initiated to investigate the efficacy of myocardial fibrosis intervention via signal transducer and activators of transcription (STAT) signaling using bone marrow (BM) mesenchymal stromal cells (MSC) in which being over-expressed with the aid of bispecific antibody (BiAb) and ultrasound-mediated microbubbles (MB). " 04/01/2011 - "This study was initiated to investigate the efficacy of myocardial fibrosis intervention via signal transducer and activators of transcription (STAT) signaling using bone marrow (BM) mesenchymal stromal cells (MSC) with the aid of bispecific antibody (BiAb) and ultrasound-mediated microbubbles (MB). " 12/01/2007 - "The purpose of this study was to assess the diagnostic value of hepatocellular nodule vascularity after microbubble injection for characterization of malignancy in patients with cirrhosis of the liver. " 10/01/2005 - "Disturbance of microbubble accumulation was correlated with sinusoidal function rather than morphological changes such as fibrosis and parenchymatitis in the animal studies. "
4.	Neoplasm Metastasis (Metastasis) 01/01/2015 - "A Novel Treatment Method for Lymph Node Metastasis Using a Lymphatic Drug Delivery System with Nano/Microbubbles and Ultrasound." 03/04/2000 - "Pulse-inversion mode imaging of liver specific microbubbles: improved detection of subcentimetre metastases." 10/10/2013 - "Three-dimensional CE-HFUS using microbubbles is an attractive, novel approach for the early detection of liver metastases through quantification of new, pathological vascular growth (i.e. " 04/01/2013 - "Contrast-enhanced ultrasound using SonoVue® (sulphur hexafluoride microbubbles) compared with contrast-enhanced computed tomography and contrast-enhanced magnetic resonance imaging for the characterisation of focal liver lesions and detection of liver metastases: a systematic review and cost-effectiveness analysis." 01/01/2012 - "DCE-US allows for real-time imaging of vascularization in bone metastases after injection of microbubbles. "
5.	Hepatocellular Carcinoma (Hepatoma) 05/01/2015 - "The objective of the study was to determine the efficacy of contrast-enhanced ultrasound (CEUS) using ultrasound (US)-specific microbubbles in guiding radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC). " 12/01/2013 - "To evaluate the efficacy of microbubble contrast ultrasound in diagnosis of hepatocellular carcinoma and to compare its results with those of magnetic resonance and histopathology. " 06/01/2008 - "Anti-angiogenic gene therapy for hepatocellular carcinoma mediated by microbubble-enhanced ultrasound exposure: an in vivo experimental study." 12/01/2015 - "Intensity-Based Assessment of Microbubble-Enhanced Ultrasonography: Phase-Related Diagnostic Ability for Cellular Differentiation of Hepatocellular Carcinoma." 12/01/2013 - "Microbubble contrast ultrasound was as accurate as magnetic resonance to evaluate hepatocellular carcinoma. "

Related Drugs and Biologics

1.	Fibrinolytic Agents (Antithrombotic Agents)
2.	Contrast Media
3.	contrast agent BR1
4.	Carbon Dioxide
5.	perfluorobutane (AI 700)
6.	Doxorubicin (Adriamycin)
7.	Liposomes (Liposome)
8.	P-Selectin
9.	Nycomed
10.	Polymers

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Microbubbles
3.	Aftercare (After-Treatment)
4.	Catheters
5.	Therapeutics