[Expression of Apoptosis-related Protein Livin and Caspase-3 in Diffuse Large B Cell Lymphoma and Its Clinical Significance].

Abstract

OBJECTIVE:

To detect the expression levels of Livin and Caspase-3 proteins in diffuse large B cell lymphoma (DLBCL), and to explore its correlation with clinicopathological characteristics, so as to provide a reference for clinical treatment and evaluation prognosis of DLBCL.

METHODS:

Immunohisto-chemical staining was performed to detect the expression of Livin and Caspase-3 in the samples from 51 DLBCL patients and 20 patients with reactive hyperplasia of lymph node (RHL). The relation between Livin and Caspase-3 with the factors influencing the prognosis of DLBCL was analyzed.

RESULTS:

Livin+ was not expressed in the tissues of RHL, but its expression rates reached to 58.82%(30/51) in 51 cases of DLBCL(P<0.05). The expression rats of Caspase-3 in DLBCL and RHL were 25.49%(13/51) and 85.0%(17/20) respectively, and the difference was statistically significant(P<0.05). The expression level of Livin in DLBCL tissues was related with clinical stage and pathological type(P<0.01, P<0.01). The expression of Livin was not obviously related with sex, age and extranodal involvement. The expression level of Caspase-3 in DLBCL tissues was related with clinical stage (P<0.05). The expression of Caspase-3 was not obviously related with sex, age, pathological type and extranodal involvement. There was a negative correlation between Livin and Caspase-3 in DLBCL(γs=-0.333,P=0.017). Kaplan-meier survival analysis revealed that the expressions of Livin and Caspase-3 were related stalistically significantly with the patients prognosis (P<0.01, P<0.05).

CONCLUSION:

Over-expression of Livin in DLBCL and DLBCL of non-GCB subtypes, and low-expression of Caspase-3 in DLBCL may play a significant role in clinical prognosis of DLBCL.

• Authors: Long Jin, Yu-Xia Sui, Zhi-Zhong Chen, Yan-Hui Li, Li-Ping Wang
• Journal: Zhongguo shi yan xue ye xue za zhi (Zhongguo Shi Yan Xue Ye Xue Za Zhi) Vol. 25 Issue 6 Pg. 1664-1669 (Dec 2017) ISSN: 1009-2137 [Print] China
• PMID: 29262894 (Publication Type: Journal Article)

Chemical References

• Adaptor Proteins, Signal Transducing
• BIRC7 protein, human
• Inhibitor of Apoptosis Proteins
• Neoplasm Proteins
• Caspase 3

Topics

• Adaptor Proteins, Signal Transducing (metabolism)
• Animals
• Apoptosis
• Caspase 3 (metabolism)
• Female
• Humans
• Inhibitor of Apoptosis Proteins (metabolism)
• Kaplan-Meier Estimate
• Lymphoma, Large B-Cell, Diffuse (metabolism, pathology)
• Male
• Neoplasm Proteins (metabolism)
• Prognosis
• Rats