Abstract | BACKGROUND/AIMS: This study investigated the radioprotective properties of three classes of CpG- oligodeoxynucleotides (CpG-ODNs) and the underlying mechanisms. METHODS: RESULTS: Survival rate of mice irradiated in 7Gy was increased from 50% to about 100% with ODNs pretreatment. ODNs administration increased the number of WBCs of irradiated mice. G-CSF, IL-6 and IFN-α levels were up-regulated with ODNs treatment. CONCLUSION: All three classes of ODNs protected mice from irradiation-induced injuries. B-class ODNs exhibited the most potent radioprotective property via the up-regulation of G-CSF and IL-6.
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Authors | Pei Zhang, Suhe Dong, Jiaming Guo, Yanyong Yang, Cong Liu, Bailong Li, Fu Gao, Xuejun Su, Jianming Cai |
Journal | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
(Cell Physiol Biochem)
Vol. 44
Issue 6
Pg. 2368-2377
( 2017)
ISSN: 1421-9778 [Electronic] Germany |
PMID | 29262401
(Publication Type: Journal Article)
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Copyright | © 2017 The Author(s). Published by S. Karger AG, Basel. |
Chemical References |
- CPG-oligonucleotide
- Interleukin-6
- Oligodeoxyribonucleotides
- Radiation-Protective Agents
- Granulocyte Colony-Stimulating Factor
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Topics |
- Animals
- Base Sequence
- Granulocyte Colony-Stimulating Factor
(blood)
- Interleukin-6
(blood)
- Leukocyte Count
- Leukocytes
(cytology, drug effects, radiation effects)
- Male
- Mice
- Mice, Inbred BALB C
- Oligodeoxyribonucleotides
(chemistry, therapeutic use)
- Radiation Injuries
(blood, drug therapy)
- Radiation-Protective Agents
(chemistry, therapeutic use)
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