Abstract | BACKGROUND: METHODS: RESULTS: In biopsy tissues, CD147 induction was detected in injured lesions representing renal inflammation. Plasma CD147 values correlated with eGFR in patients with inflammation-related kidney diseases such as IgAN, HSPN, and DKD. Particularly in IgAN patients, plasma CD147 levels were correlated with injured regions comprising more than 50% of glomeruli or with tubular atrophy/interstitial injury in biopsy tissues. Proteinuria showed a closer correlation with urinary values of CD147 and L-FABP. Of note, plasma and urinary CD147 levels showed a strong correlation with eGFR or proteinuria, respectively, only in DKD patients. CONCLUSION: Evaluation of plasma and urinary CD147 levels might provide key insights for the understanding of the activity of various kidney diseases.
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Authors | Yoshiko Mori, Tomohiro Masuda, Tomoki Kosugi, Tomoki Yoshioka, Mayuko Hori, Hiroshi Nagaya, Kayaho Maeda, Yuka Sato, Hiroshi Kojima, Noritoshi Kato, Takuji Ishimoto, Takayuki Katsuno, Yukio Yuzawa, Kenji Kadomatsu, Shoichi Maruyama |
Journal | Clinical and experimental nephrology
(Clin Exp Nephrol)
Vol. 22
Issue 4
Pg. 815-824
(Aug 2018)
ISSN: 1437-7799 [Electronic] Japan |
PMID | 29234893
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Basigin
(blood)
- Biopsy
- Cross-Sectional Studies
- Female
- Glomerulonephritis, IGA
- Humans
- Kidney
- Kidney Diseases
(blood, diagnosis, pathology)
- Male
- Middle Aged
- Young Adult
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